ArticleTranslational animal science2025
Dietary vitamin E: effect on oxidative stress, maze learning performance, and anxiety behaviors in rats.
Article in Translational animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The brain is particularly susceptible to oxidative stress (OS) and damage to membranes is associated with learning and memory decline, impacting animal welfare. Vitamin E is an antioxidant which crosses the blood-brain barrier. Our objectives were to assess the impact of dietary vitamin E concentrations (20, 90, and 400-ppm) on markers of OS, maze learning performance (MLP), and anxious behaviors in 3-wk old Long-Evans rats. Vitamin E concentrations, antioxidant enzymes (superoxide dismutase [SOD] and glutathione peroxidase [GPx]), and oxidative protein damage (protein carbonyls [PC]) were measured in plasma or serum. Lipid damage (thiobarbituric acid reactive substances [TBARS]) was measured in serum and hippocampus. Anxious behaviors, including freezing and grooming, and MLP were assessed in an eight-arm radial maze over 5 weeks. Activity of SOD was lower (
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