Evidence map›Paper›PMID 40453287›Full record

ArticleCureus2025

Japanese Traditional Herbal Medicine (Kampo Medicine) Improved Functional Hypothalamic Amenorrhea With Inherited Antithrombin Deficiency.

Mitsuyuki Takamura, Yukari Nose, Yasuyuki Ota, Mayu Omori

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mitsuyuki TakamuraCenter for Kampo Medicine, Mie University Hospital, Tsu, JPN.
Yukari NoseCenter for Kampo Medicine, Mie University Hospital, Tsu, JPN.
Yasuyuki OtaCenter for Kampo Medicine, Mie University Hospital, Tsu, JPN.
Mayu OmoriCenter for Kampo Medicine, Mie University Hospital, Tsu, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a 28-year-old Japanese woman diagnosed with functional hypothalamic amenorrhea (FHA). Although oral estrogen-progestin therapy was initially recommended, laboratory tests revealed an inherited antithrombin (AT) deficiency, which is associated with an increased risk of venous thromboembolism (VTE). To mitigate this risk, we selected Kampo medicine (Japanese traditional herbal medicine) as an alternative treatment for amenorrhea. She was prescribed

Indexed as

hypothalamic amenorrheainherited antithrombin deficiencyjapanese traditional herbal medicinekampo medicinevenous thromboembolism

Identifiers

PMID40453287
PMCPMC12123554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.