ArticleCureus2025
Fatal Disulfiram-Ethanol Reaction in a Patient With Preexisting Cardiac Comorbidities: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ethanol as a Modifier of Drug Toxicity in Humans: Pathways of Toxicity and Organ-Level Consequences.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disulfiram is widely used in the management of alcohol dependence; however, its interaction with ethanol can result in severe and life-threatening complications. This case report highlights the fatal outcome of a disulfiram-ethanol reaction (DER) in a patient with preexisting cardiac comorbidities. A 51-year-old male, recently discharged from a rehabilitation center after five months of treatment, resumed alcohol consumption despite strict medical warnings. This led to a severe DER, culminating in hypotensive shock and multi-organ failure, ultimately proving fatal despite aggressive medical intervention. Autopsy findings revealed acute tubular necrosis (ATN) secondary to persistent hypotension, exacerbated by preexisting dilated cardiomyopathy and previous myocardial infarction. This case underscores the risks of disulfiram therapy in patients with significant cardiovascular disease and highlights the need for alternative pharmacologic strategies to prevent alcohol relapse in high-risk individuals.
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Registered trials
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