Evidence map›Paper›PMID 40453223›Full record

ArticleFrontiers in pediatrics2025

Correlation between orthostatic intolerance in children and levels of ACE2-Ang(1-7)-Mas axis and vitamin D.

Yao Xiao, Jinzhi Wu, Jin Wang, Tingting He, Xiangyu Dong

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Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yao Xiao *Department of Pediatrics, The Third Hospital of Changsha (Changsha Hospital Affiliated to Hunan University), Changsha, Hunan, China.
Jinzhi Wu *Department of Pediatrics, KaiLi First People's Hospital, KaiLi, Guizhou, China.
Jin WangDepartment of Pediatrics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Tingting HeDepartment of Pediatrics, The Third Hospital of Changsha (Changsha Hospital Affiliated to Hunan University), Changsha, Hunan, China.
Xiangyu DongDepartment of Pediatrics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the correlation between orthostatic intolerance in children and levels of the ACE2-Ang(1-7)-Mas axis and vitamin D. Methods: Blood samples were collected from 84 children with orthostatic intolerance and 307 healthy controls. After matching for age and sex, 84 children from each group were studied. The orthostatic intolerance group was divided into vasovagal syncope ( Results: (1) The orthostatic intolerance group had significantly lower levels of ACE2, Ang(1-7), 25(OH)D, and hydroxylases compared to controls ( Conclusion: Reduced levels of Ang(1-7)/ACE2, 25(OH)D, and 25-hydroxylase are linked to orthostatic intolerance in children, highlighting vitamin D deficiency's role and suggesting Ang(1-7) and ACE2 as potential biomarkers. Sex does not significantly affect these biomarker levels.

Indexed as

25-hydroxylaseangiotensin (1-7)angiotensin-converting enzyme 2 (ACE2)orthostatic intolerance (OI)vitamin D

Identifiers

PMID40453223
PMCPMC12122540

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.