ArticleFrontiers in pediatrics2025
Higher induction and maintenance infliximab trough levels are associated with radiological perianal fistula healing in pediatric patients with Crohn's disease.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Literature on the association between high infliximab (IFX) trough levels and perianal fistula response in pediatric patients with perianal fistulizing Crohn's disease (PFCD) is limited. This study aimed to evaluate the association between IFX trough levels and radiological perianal fistula healing in pediatric patients with PFCD undergoing long-term IFX treatment. Methods: The study included pediatric patients (aged <18 years) diagnosed with PFCD who received IFX treatment and underwent follow-up magnetic resonance imaging (MRI) at 1 year. The primary outcome was radiological fistula healing on MRI one year after IFX treatment. Results: A total of 82 patients were included and 57 (69.5%) achieved radiological fistula healing at the 1-year follow-up. Patients with radiological fistula healing had lower rates of reoperation ( Conclusion: There was a significant association between higher serum IFX trough levels (during induction and maintenance) and radiological perianal fistula healing after 1 year of IFX treatment in pediatric patients with PFCD.
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