ArticleFrontiers in pediatrics2025
Key ultrasound predictors in the prenatal assessment of congenital pulmonary airway malformation: a single-center experience.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study assesses the sensitivity and specificity of congenital pulmonary airway malformation (CPAM) Volume Ratio (CVR) in predicting the need for fetal therapy (FT) and explores the role of additional ultrasound indicators, including the Observed/Expected Lung to Head Ratio (O/E LHR) and Mediastinal Angle Shift (MSA), in improving FT prediction. Methods: We retrospectively studied all CPAM cases referred to our Center from 2018 to 2022. FT was provided at any CVR value in cases of hydrops, rapid lesion growth, or polyhydramnios. The worst CVR, O/E LHR, and MSA values between 20 and 28 weeks of gestation were analyzed. Results: Among 62 CPAM cases, 56.4% right-sided and 43.5% left-sided. Hydrops occurred in 5 cases, all right-sided. FT was required in 14 cases (11 receiving steroids and 3 thoraco-amniotic shunt). CVR was significantly higher in the FT group compared to the non-FT group ( Conclusions: CVR is the most reliable predictor of the need for FT, even at lower thresholds. MSA can effectively complement CVR in predicting FT, and using multiple parameters may improve parental counseling and identify cases needing closer monitoring.
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