ArticleInternational journal of surgery protocols2025
Risk of breast cancer in assisted reproduction technology: a systematic review and meta-analysis protocol.
Article in International journal of surgery protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Differential Effects of 17β-Estradiol, Its Metabolites, and Cadmium on Cytotoxicity and Redox-Related Pathways in Doxorubicin-Sensitive and -Resistant Breast Cancer Cell Lines.Pharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Presently, there is a growing popularity of assisted reproductive technology (ART). Nevertheless, due to the significant fluctuations in reproductive hormone levels observed in patients receiving this novel technology, concerns have been raised regarding the potential increased risk of breast cancer associated with this treatment. The outcomes of pertinent clinical investigations exhibit significant disparities, leading to a lack of consensus regarding the association between ART and susceptibility to breast cancer. The primary objective of this study is to systematically evaluate the impact of ART on the risk of breast cancer. Method and Analysis: The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis and Meta-analysis Guidelines for Observational Studies in Epidemiology guidelines. Researchers conducted an extensive electronic search across databases including PubMed, Web of Science, Embase, and the Cochrane Library, encompassing all articles published over the last two decades (from January 2003 to December 2023). Two independent researchers meticulously examined the titles and abstracts of the literature based on predetermined inclusion criteria and research qualifications. Through collaborative deliberation, they identified the literature to be incorporated in the following analysis. Researchers will extract data in accordance with predetermined tables and perform quality assessments and implement bias control measures for each literature. Researchers will conduct a meta-analysis based on the extracted data to assess the overall risk and subgroup risks. The analysis will employ the odds ratio as the summary statistic and will use fixed or random effects models for estimation. Ethics and Dissemination: The findings of this systematic review will be disseminated through publication in peer-reviewed journals and presentation at international medical conferences, with the aim of reaching both medical professionals and the general public. As this study constitutes a systematic review, ethical approval is not required.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.