ArticleFrontiers in bioengineering and biotechnology2025
Design of AgNPs loaded γ-PGA chitosan conduits with superior antibacterial activity and nerve repair properties.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Biocompatibility and antibacterial properties of ordered PLA fiber membranes fabricated via electrospinning technology.iScience · 2026Article
- Purification, Structural Characterization, and Antibacterial Evaluation of Poly-γ-Glutamic Acid fromPolymers · 2026Article
- A Safe and Multifunctional γ-PGA Hydrogel Platform: Endotoxin-Controlled Injectable Fillers and Antimicrobial Wound Dressings.Molecules (Basel, Switzerland) · 2025Article
- Emerging Approaches to Mitigate Neural Cell Degeneration with Nanoparticles-Enhanced Polyelectrolyte Systems.Membranes · 2025Review
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Authors and funding
10 authors.
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Abstract
To address the challenge of infections during peripheral nerve defect repair, this study introduces a γ-polyglutamic acid (γ-PGA) polymers designed to encapsulate silver nanoparticles (AgNPs). The AgNPs loaded γ-PGA polymers is applied as a coating on both the inner and outer surfaces of chitosan nerve conduits, providing antibacterial protection across the conduit. The antibacterial mechanism leverages the potent antimicrobial activity of nanosilver and the negatively charged field of γ-PGA, which repels bacterial adhesion to cell membranes. This dual mechanism significantly reduces the incidence of infection, which is a critical complication during nerve repair (Tavakolian et al., 2020). Furthermore, the pH-responsive dissociation behavior of γ-PGA allows for tunable antibacterial performance by modulating the pH environment. The composite nerve conduit demonstrates sufficient mechanical strength and hydrophilic properties, ensuring its stability and compatibility for implantation.
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