Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
20 authors.
Virginia PontecorviDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Andrea AngeliNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence Via Ugo Schiff 6 50019 Sesto Fiorentino FI Italy.
Luigi CutarellaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena Via Aldo Moro 2 53100 Siena Italy.
Daniela SecciDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Michele ColucciaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.ORCID https://orcid.org/0000-0002-8703-3635
Anna TroianiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.ORCID https://orcid.org/0000-0002-6412-9407
Federico PepiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Chiara SalvittiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.ORCID https://orcid.org/0000-0002-9184-1299
Alessia Di NoiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Mattia SpanoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.ORCID https://orcid.org/0000-0001-5035-0971
Francesca ArrighiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Elena De FalcoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Corso della Repubblica 79 04100 Latina Italy.ORCID https://orcid.org/0000-0002-5220-0587
Antonella BordinDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Corso della Repubblica 79 04100 Latina Italy.
Emanuela BerrinoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Arianna GraneseDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Paola ChimentiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.
Paolo GuglielmiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome P.le A. Moro 5 00185 Rome Italy paola.chimenti@uniroma1.it paolo.guglielmi@uniroma1.it.ORCID https://orcid.org/0000-0001-5701-6925
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence Via Ugo Schiff 6 50019 Sesto Fiorentino FI Italy.ORCID https://orcid.org/0000-0003-4262-0323
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
The present study provides the design, synthesis, molecular modelling investigation and biological evaluation of a series of coumalic acid-based selective inhibitors of hCA IX and XII. Based on the previously obtained results with carboxamide analogues of coumalic acid, here we explored some modifications of the original scaffold with the aim to expand our knowledge about these compounds and to promote structure-activity relationship (SAR) studies. Structural modifications as lactone-to-lactam conversion, repositioning of the carboxylic acid moiety, and the introduction of ester or amidic linkers, as well as triazole-based elongation
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Design, synthesis, molecular modelling investigation and biological studies of novel human carbonic anhydrase inhibitors based on coumalic acid. · full record | OpenQuestion