Evidence map›Paper›PMID 40453136›Full record

ArticleBlood neoplasia2025

Clinical correlation and prognostic impact of cytogenetic clone size for myelodysplastic syndromes/neoplasm.

Zhuoer Xie, Najla Al Ali, Ling Zhang, Peter Papenhausen, Virginia Olivia Volpe, Onyee Chan, Andrew Kuykendall, Seongseok Yun, Alison Walker, Kendra Sweet and 4 more

Abstract read
In one paragraph

Article in Blood neoplasia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhuoer XieDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Najla Al AliDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Ling ZhangDepartment of Pathology, Moffitt Cancer Center, Tampa, FL.
Peter PapenhausenDepartment of Pathology, Moffitt Cancer Center, Tampa, FL.
Virginia Olivia VolpeDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Onyee ChanDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Andrew KuykendallDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Seongseok YunDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Alison WalkerDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Kendra SweetDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Jeffrey E LancetDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Eric PadronDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
David A SallmanDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.
Rami S KomrokjiDepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most myelodysplastic syndromes/neoplasms (MDS) risk stratification models dichotomize conventional cytogenetic abnormalities into present or absent, neglecting the prognostic impact of clone size (percentage of the total cells/metaphases harboring the chromosome abnormality). We investigated the prognostic value of clone size in 1001 patients with MDS using G-banding and fluorescence in situ hybridization. Clone size correlated with anemia severity and thrombocytosis in del(5q) cases, and with anemia and blast percentage in complex karyotypes.

Identifiers

PMID40453136
PMCPMC12067887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.