Evidence map›Paper›PMID 40453062›Full record

ArticleBlood neoplasia2024

Optimal number of cycles of bendamustine as initial chemoimmunotherapy for older patients with follicular lymphoma.

Christopher S Strouse, Vanessa E Siebert, Bradley T Loeffler, Bradley D McDowell, Brian J Smith, Brian K Link

Abstract read
In one paragraph

Article in Blood neoplasia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher S StrouseDivision of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA.
Vanessa E SiebertDepartment of Epidemiology, University of Iowa, Iowa City, IA.
Bradley T LoefflerHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA.
Bradley D McDowellHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA.
Brian J SmithDepartment of Biostatistics, University of Iowa, Iowa City, IA.
Brian K LinkDivision of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Building a patient-centered cancer data mart in a rural stateR50CA243692 · NCI · UNIVERSITY OF IOWA · PI MCDOWELL, BRADLEY D · 2019 to 2023
$490k
NCI NIH HHS P30 CA086862NCI NIH HHS R50 CA243692
6 · The paper itself

Abstract

Bendamustine is among the most commonly used chemoimmunotherapies for patients with follicular lymphoma (FL). It is typically delivered with a goal regimen consisting of 6 cycles, but it is possible that treatment goals could be achieved with fewer cycles, particularly in older patients. We used data from the National Cancer Institute (NCI) linkage between Surveillance, Epidemiology, and End Results program and Medicare claims to evaluate the overall survival of patients with FL receiving 3 to 4 vs 5 to 6 cycles of bendamustine. Patients receiving 1 to 2 cycles of bendamustine chemotherapy were not included. Patients receiving 5 to 6 cycles of bendamustine were significantly younger (mean age, 75.0 vs 76.2 years;

Identifiers

PMID40453062
PMCPMC12082156

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.