Evidence map›Paper›PMID 40453054›Full record

ArticleBlood neoplasia2024

Functional multiomics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma.

Priya Choudhry, Corynn Kasap, Bonell Patiño-Escobar, Olivia Gugliemini, Huimin Geng, Vishesh Sarin, Amrik Kang, Audrey Kishishita, Sham Rampersaud, Letitia Sarah and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood neoplasia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Priya ChoudhryDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Corynn KasapDivision of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA.
Bonell Patiño-EscobarDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Olivia GuglieminiDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Huimin GengDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Vishesh SarinDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Amrik KangDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Audrey KishishitaDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Sham RampersaudDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Letitia SarahDepartment of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA.
Yu-Hsiu T LinDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Neha ParanjapeDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Poornima RamkumarInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA.
Jonathan C PattonDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.
Makeba MarcoulisDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Donghui WangHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.
Paul PhojanakongHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.
Veronica SteriHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.
Byron HannHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.
Benjamin G BarwickDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA.
Martin KampmannInstitute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA.
Arun P WiitaDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
Exploiting myeloma proteome remodeling to extend proteasome inhibitor efficacyR01CA226851 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIITA, ARUN P. · 2018 to 2022
$1.6M
Stress response networks in cancer: systematic mapping and therapeutic potentialR00CA181494 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2015 to 2017
$747k
Global Assessment of Myeloma Response to ChemotherapyK08CA184116 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIITA, ARUN P. · 2014 to 2018
$684k
Stress response networks in cancer: systematic mapping and therapeutic potentialK99CA181494 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2014 to 2014
$139k
NCI NIH HHS K08 CA184116NCI NIH HHS K99 CA181494NCI NIH HHS P30 CA082103NCI NIH HHS R00 CA181494NCI NIH HHS R01 CA226851
6 · The paper itself

Abstract

CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. Pretreatment CD38 density on tumor cells is an important determinant of mAb efficacy. Several small molecules have been found to increase tumor surface CD38, with the goal of boosting mAb efficacy in a cotreatment strategy. Numerous other CD38-targeting therapeutics are currently in preclinical or clinical development. Here, we sought to extend our currently limited insight into CD38 surface expression by using a multiomics approach. Genome-wide CRISPR interference screens integrated with patient-centered epigenetic analysis confirmed known regulators of

Identifiers

PMID40453054
PMCPMC12093323

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.