ArticleFrontiers in oncology2025
A novel Tc17 population recruited by tumor cells promotes tumor progression in gastric cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The tumor microenvironment (TME) plays a crucial role in tumor progression. Recent advancements in single-cell sequencing technology have identified Tc17 cells, a newfound subset of CD8 Materials and method: We collected 296,879 cells from the single-cell sequencing data of 65 GC samples, along with spatial transcriptomic data from 10 GC samples, to further explore the role of Tc17 cells. Multicolor immunohistochemical staining demonstrated the presence of Tc17 cells in the GC TME. SCENIC analysis was performed to identify the specific transcription factors of Tc17. Pseudotime analysis of T cells was conducted to decipher the differentiation trajectory of Tc17. Additionally, cell-cell interaction analysis revealed the interactions between Tc17 cells and tumor cells. Finally, functional validation through CCK-8 proliferation assays, wound Healing assays, and transwell assays conclusively demonstrated the tumor-promoting effects of IL-17A and IL-26 on gastric tumor cells. Results: Our results indicate that Tc17 cells are absent from blood and exclusively found in tissues, with greater enrichment in tumor tissues compared to normal tissues. Among CD8 Conclusions: These findings reveal the immunosuppressive role of Tc17 cells in gastric cancer, provide a new perspective for understanding the immunosuppressive mechanism of the gastric cancer tumor microenvironment, and provide a potential target for the development of targeted therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.