SynthesisFrontiers in oncology2025
Dynamic role of gastric stem cells and chief cells in precancerous lesions of gastric cancer: global knowledge mapping and emerging trends based on bibliometric analysis from 2004 to 2024.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Extracellular Vesicle-like Associated microRNAs in Monofloral Honeys: Molecular Characterization and Functional Pathways.International journal of molecular sciences · 2026Article
- Integrated bioinformatics and experimental validation identifies SOX2 as a key therapeutic target for chronic atrophic gastritis/gastric cancer-depression comorbidity.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gastric stem cells (GSCs) and chief cells are vital for maintaining gastric epithelial homeostasis. However, under pathological conditions, these cells undergo significant functional changes, contributing to the progression of precancerous lesions of gastric cancer (PLGC). Dysregulation of key signaling pathways such as WNT, NF-κB, and YAP leads to aberrant cellular behaviors, which are implicated in the early stages of gastric carcinogenesis. This study aimed to elucidate the roles of GSCs and chief cells in maintaining gastric epithelial integrity, their contributions to the development of precancerous lesions, and the molecular mechanisms that regulate their behavior during disease progression. Methods: The study integrated bibliometric analysis, pathfinding, and data visualization using tools such as CiteSpace, VOSviewer, and R software. Functional enrichment of target genes was analyzed using KEGG and GO databases. The study focused on gastric cell changes, including differentiation, dedifferentiation, and signaling pathway activation, within the context of GSC and chief cell plasticity. Molecular markers and pathway-specific mechanisms were analyzed to clarify their contributions to gastric precancerous lesions. Results: Data from the WoSCC database from 2004 to 2024 showed a steady increase in publications on "PLGC-gastric stem cells" and "PLGC-chief cells," with the United States, China, and Japan leading in publication volume. International cooperation was evident, particularly with Canada playing a central role in academic exchanges. Key terms included stem cells, intestinal chemotaxis, and cancer, with recent focus on spasmolytic polypeptide-expressing metaplasia. Conclusion: The dynamic interactions between GSCs and chief cells are fundamental to gastric homeostasis and disease progression. GSCs primarily drive chronic inflammation-induced metaplasia and dysplastic changes, while chief cells facilitate acute epithelial repair through dedifferentiation. These findings highlight potential therapeutic targets and emphasize the importance of regulating dysregulated pathways to prevent gastric cancer. The research results will guide future studies in the fields of "PLGC-gastric stem cells" and "PLGC-chief cells," focusing on the spatiotemporal dynamics of each cell type under various injury and inflammatory conditions, as well as identifying early biomarkers of cellular changes for timely intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.