Noninvasive prediction of Ki-67 expression level in IDH-wildtype glioblastoma using MRI histogram analysis: comparison and combination of MRI morphological features.

Purpose: To assess and compare the effectiveness of magnetic resonance imaging (MRI) morphological features and MRI histogram analysis in noninvasively predicting Ki-67 expression levels in patients with IDH-wildtype glioblastoma. Methods: Forty-six cases of IDH-wildtype glioblastoma with measured Ki-67 expression levels from January 2022 to July 2024 were retrospectively collected. They were divided into Ki-67 low-level expression group (Ki-67<20%, n=20) and Ki-67 high-level expression group (Ki-67≥20%, n=26) according to Ki-67 expression level. MRI morphological features were assessed and recorded. MRI histogram analysis were performed on contrast-enhanced T1-weighted images. Differences between these parameters were compared between the two groups. The diagnostic performance was assessed by the area under the receiver operating characteristic curve (AUC). Spearman correlation was used to evaluate the relationship between histogram parameters and Ki-67 expression level. Results: Hemorrhage was more prone to occur in the Ki-67 high-level expression group ( Conclusion: Both MRI morphological features and histogram parameters could predict the Ki-67 expression level in IDH-wildtype glioblastoma, and the combined model integrating MRI morphological features and histogram parameters can be an excellent imaging biomarker for noninvasively predicting Ki-67 expression levels in patients with IDH-wildtype glioblastoma.