ReviewClinical, cosmetic and investigational dermatology2025
Adipose-Derived Stem Cell Products and Combination Therapies for the Treatment of Pathological Scars: A Review of Current Preclinical and Clinical Studies.
Review in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Advancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies.Frontiers in cell and developmental biology · 2026Review
- Absorption, Thermal Relaxation Time, and Beam Penetration Depth of Laser Wavelengths in Ex Vivo Porcine Gingival Tissues.Dentistry journal · 2025Article
- Proactive Aesthetic Strategies: Evaluating the Preventive Role of Botulinum Toxin in Facial Aging.Muscles (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pathological scars, including hypertrophic, keloid, and atrophic scars, remain challenging to treat, with current therapies offering limited success. Adipose-derived stem cell (ADSC) products, classified into cell-based therapies (stromal vascular fraction [SVF], ADSCs) and cell-free therapies (adipose tissue extract [ATE], secretomes, exosomes, extracellular vesicles), have emerged as potential treatments. Purpose: This review examines the therapeutic potential of ADSC products for pathological scars in preclinical and clinical trials, aiming to bridge the gap between experimental research and clinical application. The effectiveness of ADSC products as monotherapies and in combination with other treatments has also been explored. Methods: A comprehensive literature search followed the PICO framework, utilizing electronic databases such as PubMed and Scopus. Original research articles, including both preclinical and clinical trials, were included. Results: This review included 43 studies that demonstrated the potential of ADSC products to improve pathological scars. ADSC products improve scar texture by regulating ECM, promoting adipogenesis and angiogenesis, and reducing inflammation in hypertrophic and keloid scars. In addition, ADSC products also prevented collagen degradation in atrophic scars. Although their effectiveness varied, ADSC products also showed potential when combined with treatments such as fractional CO Conclusion: ADSC products show promise in treating pathological scars, with varying effectiveness in monotherapy or combination therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.