Evidence map›Paper›PMID 40452763›Full record

ArticleFrontiers in neurology2025

The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007-2016.

Hongjia Xu, Yiming Ding, Ye Zhang, Jianwen Li, Shiyue Zhou, Dewei Wang, Xinyue Xing, Xiaoyu Ma, Cunfu Wang, Shunliang Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongjia Xu *Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yiming Ding *Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, China.
Ye ZhangDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Jianwen LiDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shiyue ZhouDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Dewei WangDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xinyue XingDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiaoyu MaDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Cunfu WangDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shunliang XuDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Serum klotho protein is a protein with anti-aging effects. Since the relationship between serum klotho and Stroke remains rather ambiguous, this research probed into the potential correlation between serum klotho concentration and Stroke. Methods: This study employed a cross-sectional design and incorporated population data from the NHANES from 2007 to 2016. Weighted univariate and multivariate logistic regression models were utilized to inspect the relationship between klotho and Stroke. Stratified analyses and interaction tests were carried out to explore the latent correlation between klotho and Stroke. Finally, a fitted smooth curve was adopted to depict the non-linear relationship. Results: In this study, after excluding all the missing data, a total of 12,414 participants were encompassed, including 450 Stroke individuals. After adjusting for all covariates, higher klotho was associated with a lower prevalence of Stroke. According to the subgroup analyses and interaction tests, age, gender, race, BMI, hypertension, diabetes mellitus, family members, drinker and smoker were not significantly correlated with the influence of klotho and Stroke. After adjusting for all covariates, higher klotho was associated with a lower prevalence of stroke [OR: 0.68, 95% CI: 0.47-0.99]. Conclusion: This study disclosed the negative correlation between serum klotho protein levels and the prevalence of Stroke. Further prospective studies are requisite to investigate the impact of serum klotho protein levels on Stroke and determine the causal relationship.

Indexed as

atherosclerosiscross-sectional studyklothoNHANESstroke

Identifiers

PMID40452763
PMCPMC12122308

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