Evidence map›Paper›PMID 40452670›Full record

ArticleCureus2025

A Rare Case of Male Breast Cancer Presenting as a Superficial Pigmented Nipple Tumor: The Importance of a Deep Excisional Biopsy and Immunohistochemical Analysis in Diagnosis.

Ryo Nishiyori, Mayuko Goto-Umeki, Mizuho Fujinaga-Tada, Yohei Takumi, Atsushi Osoegawa, Riko Furukawa, Yuzo Oyama, Takashi Sakai, Yutaka Hatano

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryo NishiyoriDepartment of Dermatology, Oita University Faculty of Medicine, Yufu, JPN.
Mayuko Goto-UmekiDepartment of Dermatology, Oita University Faculty of Medicine, Yufu, JPN.
Mizuho Fujinaga-TadaDepartment of Dermatology, Oita University Faculty of Medicine, Yufu, JPN.
Yohei TakumiDepartment of Thoracic and Breast Surgery, Oita University Faculty of Medicine, Yufu, JPN.
Atsushi OsoegawaDepartment of Thoracic and Breast Surgery, Oita University Faculty of Medicine, Yufu, JPN.
Riko FurukawaDepartment of Diagnostic Pathology, Oita University Faculty of Medicine, Yufu, JPN.
Yuzo OyamaDepartment of Diagnostic Pathology, Oita University Faculty of Medicine, Yufu, JPN.
Takashi SakaiDepartment of Dermatology, Oita University Faculty of Medicine, Yufu, JPN.
Yutaka HatanoDepartment of Dermatology, Oita University Faculty of Medicine, Yufu, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nipple lesions present diagnostic challenges due to overlapping clinical and histopathological features. A 65-year-old male presented with a black skin lesion on his right nipple, initially suspected to be malignant melanoma. Dermoscopy suggested basal cell carcinoma, while punch biopsy findings indicated sweat gland carcinoma with negative mammaglobin staining. However, total resection revealed cord-like invasion into the deep dermis near the mammary gland, and immunohistochemistry showed mammaglobin positivity, leading to a final diagnosis of solid-type invasive ductal carcinoma of the breast. This case highlights the diagnostic challenges of male nipple tumors and underscores the need for thorough histopathological and deep-layer assessment to distinguish breast cancer from cutaneous malignancies.

Indexed as

dermoscopyinvasive ductal carcinomamale breast cancernipple tumorsweat gland carcinoma

Identifiers

PMID40452670
PMCPMC12127009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.