Evidence map›Paper›PMID 40452635›Full record

Trial reportJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2025

Cost-Effectiveness of Personalised Nutrition in Adults With Overweight and Obesity: PREVENTOMICS Studies in Poland and the UK.

Milanne Maria Johanna Galekop, Philip C Calder, Ella J Baker, Joanna Góralska, Urszula Raźny, Malgorzata Malczewska-Malec, Carin A Uyl-de Groot, William Ken Redekop

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milanne Maria Johanna GalekopErasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-0760-9850
Philip C CalderSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Ella J BakerSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Joanna GóralskaDepartment of Clinical Biochemistry, Genetics and Nutrigenomics, Chair in Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
Urszula RaźnyDepartment of Clinical Biochemistry, Genetics and Nutrigenomics, Chair in Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
Malgorzata Malczewska-MalecDepartment of Clinical Biochemistry, Genetics and Nutrigenomics, Chair in Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
Carin A Uyl-de GrootErasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
William Ken RedekopErasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.

Funding

This study was funded by the European Union's Horizon 2020 research and innovation program (Grant 818318).
6 · The paper itself

Abstract

backgroundWe assessed the cost-effectiveness of personalised nutrition in adults with overweight/obesity in Poland and the United Kingdom (UK) using the results of two randomised controlled trials (RCTs).

methodsThe 4-month RCTs compared three interventions: personalised plan (PP) plus behavioural change (PP+B), PP only, and a control. Outcomes included body mass index (BMI), health-related quality of life (EQ-5D-5L), quality-adjusted life years (QALYs), and costs (2020 British pounds). A Markov model estimated lifetime cost-effectiveness. Different sensitivity analyses were performed.

resultsParticipants were randomised to PP+B, PP, and control groups in Poland (n = 89, n = 88, n = 88) and the UK (n = 20, n = 19, n = 15). Comparing BMI reductions of PP+B and PP with control in both countries showed no significant differences, but wide confidence intervals (CIs) were observed (e.g., PP+B vs. control-Poland: -0.20, 95% CI: -0.86, 0.45 kg/m

conclusionsThe PREVENTOMICS interventions may offer a cost-effective approach to reduce weight and avoid its related complications in both countries. Future studies should be larger and/or longer to reduce uncertainty about effectiveness. CLINICAL TRIAL REGISTRATION NUMBERS: Poland ISRCTN51509551 and the UK ISRCTN46063864.

Indexed as

Cost-Effectiveness AnalysisObesityOverweightPrecision MedicineAdultBody Mass IndexFemaleHumansMaleMiddle AgedPolandQuality-Adjusted Life YearsQuality of LifeUnited Kingdomcost‐effectiveness analysisobesityoverweightpersonalised nutrition

Identifiers

PMID40452635
PMCPMC12128005

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.