Evidence map›Paper›PMID 40452512›Full record

ArticleEpidemiology and infection2025

Case-control study of leptospirosis in Aotearoa New Zealand reveals behavioural, occupational, and environmental risk factors.

Shahista Nisa, Enrico Ortolani, Emilie Vallée, Jonathan Marshall, Julie Collins-Emerson, Polly Yeung, Gerard Prinsen, Jackie Wright, Tanya Quin, Ahmed Fayaz and 4 more

Abstract read
In one paragraph

Article in Epidemiology and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shahista NisaMolecular Epidemiology and Public Health Laboratory, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.ORCID 0000-0003-1721-0808
Enrico OrtolaniMolecular Epidemiology and Public Health Laboratory, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Emilie ValléeEpiCentre, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.ORCID 0000-0002-3145-5468
Jonathan MarshallSchool of Mathematical and Computational Sciences, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Julie Collins-EmersonMolecular Epidemiology and Public Health Laboratory, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Polly YeungSchool of Social Work, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Gerard PrinsenSchool of People, Environment and Planning, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Jackie Wrighthttps://ror.org/0405trq15Institute of Environmental Science and Research, Health Security, Christchurch, New Zealand.ORCID 0000-0001-6462-4769
Tanya QuinRural Health Unit, https://ror.org/03b94tp07University of Auckland, Auckland, New Zealand.
Ahmed FayazMolecular Epidemiology and Public Health Laboratory, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Stuart LittlejohnMolecular Epidemiology and Public Health Laboratory, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.
Michael G BakerDepartment of Public Health, https://ror.org/01jmxt844University of Otago, Wellington, New Zealand.
Jeroen DouwesCentre for Public Health Research, https://ror.org/052czxv31Massey University, Wellington, New Zealand.
Jackie BenschopMolecular Epidemiology and Public Health Laboratory, School of Veterinary Science, https://ror.org/052czxv31Massey University, Palmerston North, New Zealand.

Funding

Health Research Council of New Zealand F-112870
6 · The paper itself

Abstract

Leptospirosis in NZ has historically been associated with male workers in livestock industries; however, the disease epidemiology is changing. This study identified risk factors amid these shifts. Participants (95 cases:300 controls) were recruited nationwide between 22 July 2019 and 31 January 2022, and controls were frequency-matched by sex (90% male) and rurality (65% rural). Multivariable logistic regression models, adjusted for sex, rurality, age, and season-with one model additionally including occupational sector-identified risk factors including contact with dairy cattle (aOR 2.5; CI: 1.0-6.0), activities with beef cattle (aOR 3.0; 95% CI: 1.1-8.2), cleaning urine/faeces from yard surfaces (aOR 3.9; 95% CI: 1.5-10.3), uncovered cuts/scratches (aOR 4.6; 95% CI: 1.9-11.7), evidence of rodents (aOR 2.2; 95% CI: 1.0-5.0), and work water supply from multiple sources-especially creeks/streams (aOR 7.8; 95% CI: 1.5-45.1) or roof-collected rainwater (aOR 6.6; 95% CI: 1.4-33.7). When adjusted for occupational sector, risk factors remained significant except for contact with dairy cattle, and slaughter without gloves emerged as a risk (aOR 3.3; 95% CI: 0.9-12.9). This study highlights novel behavioural factors, such as uncovered cuts and inconsistent glove use, alongside environmental risks from rodents and natural water sources.

Indexed as

LeptospirosisOccupational ExposureAdolescentAdultAgedAnimalsCase-Control StudiesCattleFemaleHumansMaleMiddle AgedNew ZealandRisk FactorsYoung AdultLeptospirosisLivestockRodentWaterZoonotic

Identifiers

PMID40452512
PMCPMC12171903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.