Evidence map›Paper›PMID 40452498›Full record

SynthesisCNS spectrums2025

A systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia.

Kyle Valentino, Kayla Teopiz, Sabrina Wong, Gia Han Le, Sebastian Badulescu, Danica Johnson, Roger Ho, Taeho Greg Rhee, Bing Cao, Joshua Rosenblat and 2 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in CNS spectrums, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kyle ValentinoBrain and Cognition Discovery Foundation, Toronto, ON, Canada.
Kayla TeopizBrain and Cognition Discovery Foundation, Toronto, ON, Canada.
Sabrina WongBrain and Cognition Discovery Foundation, Toronto, ON, Canada.
Gia Han LeBrain and Cognition Discovery Foundation, Toronto, ON, Canada.
Sebastian BadulescuMood Disorder Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.
Danica JohnsonMood Disorder Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.
Roger HoDepartment of Psychological Medicine, Yong Loo Lin School of Medicine.
Taeho Greg RheeDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Bing CaoKey Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, P. R. China.ORCID 0000-0001-5963-2676
Joshua RosenblatDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Rodrigo MansurMood Disorder Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-3968-3297
Roger S McIntyreDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-4733-2523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suicide accounts for over 700,000 deaths per year globally and remains a public health priority. Evidence suggests that sleep-related interventions may be effective in reducing depressive symptom severity and suicidal thoughts in patients diagnosed with depression and comorbid insomnia. This study aims to systematically review the efficacy of sedative-hypnotics and/or cognitive behavioral therapy for insomnia (CBT-I) on measures of suicidality.In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, PubMed, Medline, Cochrane Library, Embase, Scopus, and Web of Science were searched from inception to July 30, 2024. Studies were included if they (1) were randomized controlled trials (RCTs) and (2) reported on suicide-related measures associated with sleep interventions as a primary outcome, secondary outcome, or a safety measure. We endeavored to define and operationalize suicidality as suicidal ideation (SI), suicide attempts (SA), and suicide completion (SC). In cases where study authors failed to separate these three dimensions, the term "suicidality" was applied.Eighteen studies were identified meeting inclusion criteria, comprised of studies investigating benzodiazepines (

Indexed as

Cognitive Behavioral TherapyHypnotics and SedativesSleep Initiation and Maintenance DisordersSuicide PreventionHumansSuicidal IdeationHypnotics and SedativesCBT-Idepressionorexin receptor antagonistsSedative-hypnoticssuicidality

Identifiers

PMID40452498
PMCPMC13064792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.