Evidence map›Paper›PMID 40452484›Full record

ArticleTherapeutic delivery2025

Enhanced transdermal delivery of curcuminoids from statistically designed nano-emulgel formulated using Eucalyptus oil.

Shilpi Arora, Deepak Kaushik, Mohammad Akhlaquer Rahman, Rohit Dutt, Abhishek Tiwari, Sarita Garg, Rajeev K Singla, Vineet Mittal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shilpi AroraDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
Deepak KaushikDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
Mohammad Akhlaquer RahmanDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Rohit DuttGandhi Memorial National College, Ambala Cantt, India.
Abhishek TiwariAmity Institute of Pharmacy, Amity University Lucknow Campus, Lucknow, Noida, India.
Sarita GargVaish Institute of Pharmaceutical Education & Research, Rohtak, India.
Rajeev K SinglaDepartment of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Vineet MittalDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.ORCID 0000-0002-0980-5628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe present research aimed to develop a transdermal formulation of Curcuminoids utilizing eucalyptus oil as a permeation enhancer. MATERIAL &

methodDesign-based optimization studies were performed to select the concentration of excipients and to prepare the nano emulsion. The eucalyptus oil was selected to develop the curcuminoids emulgel. The developed emulgel was evaluated for permeation using human skin and analyzed by HPLC. The emulgel was also evaluated for anti-inflammatory potential as compared to Curcuminoid gel formulation without permeation enhancer.

resultsPermeability studies performed using human skin with subsequent analysis of the samples by HPLC revealed that developed formulation was three times better as compared to formulation without permeation enhancer. The enhanced penetration attributed to polarity alteration, liquidation, and disruption of lipid bilayer by the terpenes present in essential oils. Literature also suggested that monoterpenes like 1,8 cineole could disrupt the lipid bilayer of skin and thus result in better penetration. The improved permeability could also be responsible for the enhanced anti-inflammatory potential (

conclusionIn nutshell, we can conclude that curcuminoids have the potential to be developed as emulgel with eucalyptus oil as a penetration enhancer.

Indexed as

CurcuminEucalyptus OilNanoparticlesOils, VolatilePlant OilsAdministration, CutaneousAnti-Inflammatory AgentsChemistry, PharmaceuticalEmulsionsEucalyptusExcipientsGelsHumansPermeabilitySkinSkin AbsorptionAnti-Inflammatory AgentsCurcuminEmulsionsEucalyptus OilExcipientsGelsOils, VolatilePlant OilscurcuminoidsEmulgeleucalyptus oilHPLCnanoformulationpermeation

Identifiers

PMID40452484
PMCPMC12218487

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.