Evidence map›Paper›PMID 40452415›Full record

Observational studyNeurourology and urodynamics2025

Relative Impact of Male Urinary Conditions on Overall Quality of Life.

Vishrudh Vasudevan, Golena Moncaleano Fernandez, Rodney L Dunn, Martin Miner, Claus Roehrborn, Raymond Rosen, Allen Seftel, Cathie Spino, John T Wei, Aruna V Sarma and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurourology and urodynamics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Associations of pain in young men presenting with lower urinary tract symptoms.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vishrudh VasudevanCollege of Medicine, Central Michigan University, Mount Pleasant, Michigan, USA.
Golena Moncaleano FernandezDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-6578-3622
Rodney L DunnDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Martin MinerDepartment of Urology, Brown University, Providence, Rhode Island, USA.
Claus RoehrbornDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Raymond RosenDepartment of Psychiatry, University of California San Francisco, San Francisco, California, USA.
Allen SeftelDepartment of Surgery, Rowan University, Camden, New Jersey, USA.
Cathie SpinoDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
John T WeiCollege of Medicine, Central Michigan University, Mount Pleasant, Michigan, USA.
Aruna V SarmaDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-3420-8021
BPH Registry and Patient Survey Steering Committee

Funding

This research was supported by contracts with Sanofi-Aventis.
6 · The paper itself

Abstract

objectivesTo assess the impact of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) and other urinary conditions on quality of life (QoL), in comparison to other comorbidities, after adjusting for lifestyle and demographic factors.

methodsThe BPH Registry and Patient Survey is a multicenter, longitudinal, observational database of management practices and patient outcomes in a population of 6924 patients with BPH in the USA, managed with watchful waiting or pharmacotherapy. QoL was assessed using the Medical Outcomes Study-Short Form 12 physical (SF12 PCS) and mental health (SF12 MCS) component scores. The following urinary conditions were evaluated: lower urinary tract symptoms (LUTS) assessed using the International Prostate Symptom Score (IPSS), physician diagnosed urinary incontinence (UI), overactive bladder (OAB) and urinary tract infection (UTI). Associations between QoL and urinary conditions and other co-morbidities adjusted for demographic/lifestyle factors were estimated in 3818 men with complete data using linear regression models.

resultsApproximately 21.1% of the population reported having at least one urinary condition; however, prevalence of specific urinary conditions was less than other co-morbidities. After adjusting for age, marital status, education, income, employment, alcohol use and smoking status, severe LUTS (IPSS ≥ 20) and UI were associated with a 3.9- and 2.9-point decrease in the SF12 PCS, respectively. These associations were similar to those observed with arthritis and depression, and more significant than the PCS reductions associated with cardiovascular disease (CVD), cancer, and diabetes. Urinary conditions also led to greater reductions in the SF12 MCS compared to other comorbidities, with only depression showing a greater impact on MCS scores.

conclusionsThese results highlight that the impact of urinary conditions, particularly LUTS and UI, on QoL is similar to, if not more substantial than, that of other major chronic diseases. These conditions affect not only the physical component of QoL but also significantly influence the mental domains.

Indexed as

Lower Urinary Tract SymptomsProstatic HyperplasiaQuality of LifeAgedAged, 80 and overComorbidityHumansLongitudinal StudiesMaleMiddle AgedPrevalenceRegistriesUnited StatesUrinary Bladder, OveractiveUrinary Incontinence

Identifiers

PMID40452415
PMCPMC12264456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.