ArticleJournal of neurochemistry2025
Altered Vesicular Acetylcholine Transporter Expression Regulates Acetylcholine Abundance in the Brain of Drosophila melanogaster.
Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The neurotransmitter acetylcholine (ACh) plays a central role in the regulation of vital neurological processes like cognition. As a result, increases or decreases in neuronal cholinergic signaling lead to an impairment in learning and memory. Although much about how acetylcholine is regulated is known, the mechanism through which alterations in cholinergic signaling affect changes in ACh-linked behavior is not fully understood. Importantly, the nature of the relationship between vesicular acetylcholine packaging and its release at the synaptic cleft is also unclear. We are interested in using the vesicular acetylcholine transporter (VAChT), which mediates the packaging and transport of acetylcholine (ACh) for exocytotic release, to elucidate the ways in which ACh loading alters its release and metabolism. We used both an overexpression of VAChT and two Vacht mutant lines, Vacht
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