Evidence map›Paper›PMID 40452401›Full record

ArticleJournal of chemical information and modeling2025

Hierarchical Extended Linkage Method (HELM)'s Deep Dive into Hybrid Clustering Strategies.

Lexin Chen, Jherome Brylle Woody Santos, Jokent Gaza, Alberto Perez, Ramón Alain Miranda-Quintana

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Pathway representationDigital discovery · 2026
    Article
  2. Article
  3. ScalingJournal of chemical information and modeling · 2026
    Article
  4. Article
  5. Article
  6. Beyond Classical Force Fields: Physics-Driven Assessment of the Grappa Machine-Learned Force Field on the FoldBind Dataset.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. clusttraj: A Solvent-Informed Clustering Tool for Molecular Modeling.Journal of chemical theory and computation · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lexin ChenDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville 32611, Florida, United States.ORCID 0000-0002-9528-942X
Jherome Brylle Woody SantosDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville 32611, Florida, United States.
Jokent GazaDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville 32611, Florida, United States.ORCID 0000-0002-7836-4539
Alberto PerezDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville 32611, Florida, United States.ORCID 0000-0002-5054-5338
Ramón Alain Miranda-QuintanaDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville 32611, Florida, United States.ORCID 0000-0003-2121-4449

Funding

Tackling Big Data problems in biomedical sciences with extended similarity methodsR35GM150620 · NIGMS · UNIVERSITY OF FLORIDA · PI Ramon Alain Miranda Quintana · 2023 to 2026
$1.4M
NIGMS NIH HHS R35 GM150620
6 · The paper itself

Abstract

Clustering remains a key tool in the analysis of molecular dynamics (MD) simulations, from the preparation of kinetic models to the study of mechanistic pathways and structural determination. It is no surprise then that multiple algorithms are currently used in the MD community, with

Indexed as

Molecular Dynamics SimulationAlgorithmsCluster AnalysisDNAProtein FoldingProteinsDNAProteins

Identifiers

PMID40452401
PMCPMC13217605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.