ArticleJournal of global health2025
Temporospatial variation in environmental risk factors and related gastric cancer incidence: a registry-based study in an area with the largest gastric cancer burden in China.
Article in Journal of global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics.Oncology reports · 2026Article
- Soil properties and spatial distribution of chronic gastritis in Yanshan County, China: a spatial epidemiological study.BMC gastroenterology · 2026Article
- Why internists should care about Helicobacter pylori: recapitulating gastric cancer prevention.Internal and emergency medicine · 2025Article
- The Roles and Implications of m6A Methylation in Radiotherapy for Gastrointestinal Tumors.Dose-response : a publication of International Hormesis SocietyReview
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22 authors.
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Abstract
Background: Gastric cancer is a formidable global heath challenge, especially in China. We aimed to investigate temporal trends and spatial variations of gastric cancer incidence and mortality in Gansu Province, which has the highest incidence rate of gastric cancer in China, and sought to explore the role of various geographic and environmental factors played in the variations of incidence rates of gastric cancer. Methods: We sourced the incidence and mortality data for gastric cancer from the China Cancer Registry Annual Report and environmental data from National Soil Series Survey and Compilation of Soil Series of China and China National Environmental Monitoring Centre. We used joinpoint regression models to examine the temporal trends in age-standardised incidence rate (ASIR) and age-standardised mortality rate (ASMR) for gastric cancer between 2010 and 2018. We used the Pearson correlation coefficient, robust linear regression, and least-squares regression models to explore the associations between environmental parameters and gastric cancer incidence. Results: The ASIR of gastric cancer per 100 000 population in Gansu Province showed a slightly increasing trend from 2010 (77.75; 95% confidence interval (CI) = 73.98, 81.52) to 2014 (85.20; 95% CI = 80.36, 90.04) and then started to decrease to 51.77 (95% CI = 49.14, 54.40) in 2018. The mortality rate of gastric cancer per 100 000 population remained stable from 2010 (55.69; 95% CI = 52.38, 59.01) to 2017 (51.06; 95% CI = 48.11, 54.01), while the rate showed a noticeable decline in 2018 (33.37; 95% CI = 31.26, 35.48). In 2018, significant variations in the ASIR (more than 5-fold) and ASMR (more than 11-fold) were observed across 15 registries in Gansu Province. Associations between soil properties at different depths and ASIR were calculated for 15 registries in Gansu Province, and statistically significant indicators included soil pH, total nitrogen density (TND), total phosphorus (TP), and soil organic carbon density (SOCD) (P < 0.05). No statistically significant correlation was found between ASIR and ambient air pollutants and surface water properties. The environmental variables explained about 37.9% of the variability in regional level ASIR of gastric cancer (adjusted R Conclusions: We observed significant geospatial variations in the ASIR and ASMR of gastric cancer in Gansu Province, which has the highest incidence rate of gastric cancer in China, as well as a novel correlation between the usage of chemical fertilisers and the incidence of gastric cancer, highlighting the need for further research in this area.
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