Observational studyAnnals of African medicine2026
Effect of 0.1% Ropivacaine with Dexmedetomidine Compared to 0.125% Bupivacaine with Dexmedetomidine in Ultrasound-Guided Femoral Nerve Block for Postoperative Analgesia after Total Knee Arthroplasty - A Comparative Observational Study.
Observational study in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of adding dexmedetomidine to fascia iliaca compartment block on postoperative analgesia in patients undergoing femoral fractures surgery: A randomized double-blind clinical trial.The Journal of international medical research · 2026Trial
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimTotal knee arthroplasty (TKA) is a common procedure for severe knee joint conditions, requiring effective postoperative pain management to improve outcomes and minimize side effects. This study aims to compare the analgesic efficacy and safety of 0.1% ropivacaine versus 0.125% bupivacaine, each combined with dexmedetomidine, for femoral nerve block in TKA.
methodsThis comparative observational study was conducted at KMC Hospitals, Mangalore, from September 2022 to January 2024. Seventy-two patients undergoing spinal anesthesia for unilateral TKA were included, with 36 in each group. Group R received 0.1% ropivacaine with 0.75 μg/kg dexmedetomidine and Group B received 0.125% bupivacaine with 0.75 μg/kg dexmedetomidine. Pain was assessed using the Visual Analog Scale (VAS) at various time points postoperatively. Other outcomes included SPO2 levels, blood pressure, nausea, vomiting, and time to rescue analgesia.
resultsBoth groups showed comparable pain relief, with no significant differences in VAS scores at rest or during motion at 24 h postoperation. SPO2 levels were similar across groups, with a significant difference only at 10 min postoperation. Blood pressure measurements showed no significant differences. Nausea and vomiting rates were high but similar between groups. The time to first rescue analgesia was slightly longer for the bupivacaine group (318 min vs. 305 min).
conclusionBoth 0.1% ropivacaine and 0.125% bupivacaine, each with dexmedetomidine, provide effective analgesia for TKA with minimal impact on vital signs. Bupivacaine showed a trend toward lower blood pressure, which may benefit cardiovascular patients. Further research with larger cohorts and extended monitoring is recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.