Evidence map›Paper›PMID 40452261›Full record

SynthesisEuropean journal of neurology2025

Role of Imaging in Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review.

Stefano Tozza, Emanuele Cassano, Carmen Erra, Mario Muto, Francesco Habetswallner, Fiore Manganelli

Abstract readSystematic Review
In one paragraph

Synthesis in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefano TozzaDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Naples, Italy.ORCID 0000-0002-9672-4577
Emanuele CassanoDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Naples, Italy.
Carmen ErraClinical Neurophysiology Unit, Cardarelli Hospital, Naples, Italy.
Mario MutoNeuroradiology Department, Cardarelli Hospital, Naples, Italy.
Francesco HabetswallnerClinical Neurophysiology Unit, Cardarelli Hospital, Naples, Italy.
Fiore ManganelliDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a treatable immune-mediated neuropathy with a relapsing-remitting course and symmetrical proximal and distal weakness. Diagnosis relies on nerve conduction studies (NCS) to detect demyelination but can be difficult in atypical cases. In such instances, nerve ultrasound (US) and MRI of the brachial and lumbosacral plexuses help improve diagnostic accuracy and guide treatment. This review examines the role of imaging in CIDP, focusing on its contribution to diagnosis, prognosis, and follow-up.

methodsA total of 183 articles were identified in the PubMed database using the search terms: "CIDP AND imaging," "CIDP AND ULTRASOUND," and "CIDP AND MRI." Based on predefined inclusion criteria, 106 articles were selected for review (63 related to US and 43 to MRI). From each included study, data were extracted on the study population, imaging protocols used, outcome measures applied, and main findings relevant to the review's aim.

resultsThe most used ultrasound and MRI protocols, along with their associated outcome measures, are discussed. Furthermore, the roles of each imaging modality in diagnosis, prognosis, and follow-up are analysed.

conclusionAlthough NCS remain the primary instrumental test for the diagnosis of CIDP, US and MRI can be valuable adjuncts in cases with diagnostic uncertainty. Additionally, these imaging modalities may be more useful than NCS in prognostic evaluation, helping in predict treatment response and monitoring subclinical disease activity.

Indexed as

Magnetic Resonance ImagingPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingHumansNeural ConductionUltrasonographyCIDPMRIultrasound

Identifiers

PMID40452261
PMCPMC12127570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.