ArticleACS applied materials & interfaces2025
Real-Time and Highly Sensitive Detection of Matrix Metalloproteinase 9 (MMP-9) in Tears Using Aptamer Functionalized Electrolyte-Gated IGZO Thin-Film Transistors.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Nucleic Acid-Based Field-Effect Transistor Biosensors.Biosensors · 2026Review
- Ocular social jetlag: a driver of immune-metabolic dysfunction in dry eye disease.Frontiers in immunology · 2026Review
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Authors and funding
5 authors.
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Abstract
Dry eye disease (DED) is a common disorder characterized by unstable tear film homeostasis. Its symptoms range from foreign body sensations to pain and fluctuations in visual function. Current diagnostics include physical examination and ocular surface imaging. Matrix metalloproteinase-9 (MMP-9) in tears correlates with clinical signs of DED; however, because of the limited sample volume, quantitative and real-time detection of MMP-9 is a significant need, complicated by the biochemical complexity of tears. We developed an ultrasensitive, real-time MMP-9 sensor based on electrolyte-gated indium-gallium-zinc oxide thin-film transistors (IGZO-EGTFTs), capable of analyzing submicroliter sample volumes. The sensor surface was functionalized at the nanoscale to improve the binding capability of the aptamer, achieving a limit of detection of 1 fg/mL. The sensor demonstrated excellent reproducibility over a dynamic detection range spanning 8 orders of magnitude up to 100 ng/mL (10
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