Evidence map›Paper›PMID 40452136›Full record

Observational studyPediatric blood & cancer2025

Long-Term Outcome of Young Infants With Suspected Neuroblastoma following Observation as Primary Therapy: A Report From the Children's Oncology Group.

Hetal Dholaria, Arlene Naranjo, Fan F Zhang, Wendy B London, Lisa Diller, Robert C Shamberger, Carol E Barnewolt, Mary Lou Schmidt, John M Maris, Sue L Cohn and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Diagnosis and management of neuroblastoma in children.World journal of pediatric surgery · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hetal DholariaDepartment of Oncology, Perth Children's Hospital, Perth, Australia.ORCID 0000-0003-1713-3822
Arlene NaranjoChildren's Oncology Group Statistics and Data Center, University of Florida, Gainesville, Florida, USA.
Fan F ZhangChildren's Oncology Group Statistics and Data Center, Monrovia, California, USA.ORCID 0000-0002-1606-7766
Wendy B LondonDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.ORCID 0000-0003-3571-6538
Lisa DillerDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Robert C ShambergerDepartment of Surgery, Boston Children's Hospital and Dana Farber Cancer Center, Boston, Massachusetts, USA.
Carol E BarnewoltDepartment of Radiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Mary Lou SchmidtDepartment of Pediatrics, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
John M MarisChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8088-7929
Sue L CohnUniversity of Chicago Medical Center, Chicago, Illinois, USA.
Rochelle BagatellChildren's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5729-8819
Jed G NuchternBaylor College of Medicine, Houston, Texas, USA.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ANDERSON, JAMES R · 2003 to 2013
$67.5M
Chair's U10CA098543NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCTN Operations Center U10CA180886NCTN Statistics & Data Center U10CA180899Statistics & Data Center U10CA098413
6 · The paper itself

Abstract

Several studies have established that patients with localized perinatal neuroblastoma can be safely observed; however, long-term outcomes have not been previously reported. We evaluated long-term outcomes of infants with suspected perinatal neuroblastoma enrolled on the Children's Oncology Group (COG) ANBL00P2, which included an expectant observation approach. Among 87 eligible patients, the 10-year event-free survival (EFS) was 93.7%, and overall survival (OS) was 98.0%. Most tumors regressed spontaneously; only three patients reported progression to higher stage disease. This report reinforces the long-term safety of non-interventional management in perinatal neuroblastoma, sparing infants unnecessary surgery and associated risks.

Indexed as

NeuroblastomaWatchful WaitingAdolescentChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornKaplan-Meier EstimateMaleMedical OncologyPrognosisSurvival RateTime Factors

Identifiers

PMID40452136
PMCPMC12442495

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.