Evidence map›Paper›PMID 40452066›Full record

ArticleBiology of sex differences2025

Associations of social determinants of health on likelihood of systemic hormone therapy use in midlife women.

Juliana M Kling, Anna E Abraham, Ekta Kapoor, Kristin Cole, Mariam Saadedine, Chrisandra Shufelt, Stacey J Winham, Stephanie S Faubion

Abstract read
In one paragraph

Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juliana M KlingMayo Clinic Center for Women's Health, Mayo Clinic, 200 First St. SW, Rochester, Rochester, Minnesota, MN, 55905, USA. Kling.Juliana@mayo.edu.
Anna E AbrahamUniversity of Arizona College of Medicine, 475 N 5th St, Phoenix, Phoenix, Arizona, AZ, 85004, USA.
Ekta KapoorMayo Clinic Center for Women's Health, Mayo Clinic, 200 First St. SW, Rochester, Rochester, Minnesota, MN, 55905, USA.
Kristin ColeDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, Rochester, Minnesota, MN, 55905, USA.
Mariam SaadedineDivision of General Internal Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Jacksonville, Florida, FL, 32224, USA.
Chrisandra ShufeltMayo Clinic Center for Women's Health, Mayo Clinic, 200 First St. SW, Rochester, Rochester, Minnesota, MN, 55905, USA.
Stacey J WinhamDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, Rochester, Minnesota, MN, 55905, USA.
Stephanie S FaubionMayo Clinic Center for Women's Health, Mayo Clinic, 200 First St. SW, Rochester, Rochester, Minnesota, MN, 55905, USA.

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

objectiveSocial determinants of health (SDOH) can have a significant impact on women's health and quality of life. Little is known about the impact of SDOH during menopause, and whether certain SDOH impact the likelihood of using systemic hormone therapy (HT). Our objective was to evaluate the impact of SDOH on the likelihood of HT utilization among midlife women.

designMidlife women between the ages of 45-60 years were surveyed about their menopause experience between March and June of 2021. The questionnaire included information on medications used to treat menopause symptoms. From the electronic medical record demographic information and self-reported SDOH data were obtained, including the amount of exercise/physical activity, whether the participants felt stressed, social interactions, abuse in the last year, ability to pay for basics, diet, alcohol intake, smoking status, and whether participants had regular dentist visits. SDOH were compared between using/not using HT currently.

resultsOne thousand nine hundred and eighty-eight women aged 45-60 years who received primary care at one of four geographic Mayo Clinic sites completed the survey and filled out SDOH questions within 2 years. Women were 54.4 years of age on average (SD 4.2), with a mean BMI of 30.2 (SD 7.5), and a majority White (97%). 258 (13.0%) women were currently using HT. In univariate analysis, women were less likely to be using HT if they had higher BMI (per 1 kg/m

conclusionCertain SDOH were associated with HT use for menopause treatment. Favorable SDOH likely correlate with better access to menopause care. To assure equitable menopause treatment for all women, clinicians should evaluate and address SDOH with their midlife women patients.

Indexed as

Estrogen Replacement TherapyHormone Replacement TherapyMenopauseSocial Determinants of HealthFemaleHumansMiddle AgedSurveys and QuestionnairesWomen's HealthHealth equityMenopausal hormone therapyMenopause careMidlife womenSocial determinants of healthWomen’s health

Identifiers

PMID40452066
PMCPMC12128302

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.