ArticleParasites & vectors2025
Dynamics of vector competence for dengue virus type 2 in rural and urban populations of Aedes albopictus: implications for infectious disease control.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Population genetic diversity and natural Wolbachia infection in Aedes aegypti from Pakistan.Parasites & vectors · 2025Article
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7 authors.
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Abstract
backgroundUnderstanding the intrinsic factors that influence mosquito vector competence (VC) to pathogens is crucial for assessing the risk of disease transmission in both rural and urban environments. We assessed the VC of Aedes albopictus mosquitoes from urban (dengue-endemic) and rural (dengue-free) areas in Guangzhou, China, for dengue virus-2 (DENV-2), while also examining intrinsic factors such as Wolbachia and immune-related gene expression influencing VC.
methodsAdult females of rural, urban, and laboratory (control) populations of Ae. albopictus were orally exposed to a freshly prepared suspension of the DENV-2 New Guinea C strain (GenBank: AF038403.1), with a final titer of 1 × 10
resultsAt 7 dpe, virus proliferation in rural mosquitoes was similar to that in urban mosquitoes (P = 0.10). By 14 dpe, rural mosquitoes showed a significantly lower status of virus dissemination (P < 0.04) and transmission (P < 0.012). Wolbachia (-0.12 < r < -0.92) and immune effectors (-0.025 < r < -0.568) were negatively correlated with DENV in all mosquitoes, with more negative values indicating a stronger inverse relationship. The wAlbA and wAlbB strains exhibited similar densities across all the mosquito populations, with wAlbB revealing a slightly greater abundance in rural mosquitoes, although the difference was not significant. Elevated Relish 2 (Rel2), defensin A (DefA), and the signal transducers and activators of transcription (STAT) levels indicate activation of the Toll and JAK-STAT pathways, contributing to resistance against DENV replication and reduced VC in rural mosquitoes.
conclusionsThis study indicates that rural Ae. albopictus mosquitoes may possess intrinsic barriers limiting their VC for DENV-2, offering valuable preliminary insights into VC across geographically distinct populations. However, further research across a broader range of urban and rural locations is needed to validate these findings and better understand the local factors influencing VC. Such insights are vital for public health, as they can help prioritize locations for dengue surveillance and effective vector control. Future studies should investigate the roles of intestinal microflora and immune pathways across diverse mosquito populations to better understand these dynamics and improve our knowledge of mosquito-borne disease transmission in different environments.
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