Evidence map›Paper›PMID 40452038›Full record

Trial reportBMC women's health2025

A randomized trial to evaluate the impact of breast density notification on anxiety, breast cancer worry, and perceived risk among Latinas at a federally qualified health center : Breast density notification and anxiety, breast cancer worry, and perceived risk among Latinas.

Karthik Ghosh, Sarah M Jenkins, Jennifer L Ridgeway, Jessica D Austin, Bijan J Borah, Bhavika Patel, Deborah J Rhodes, Aaron D Norman, Edna P Ramos, Matt Jewett and 5 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02910986 (Latinas LEarning About Density), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02910986 nacompletednot on this map

Latinas LEarning About Density (LLEAD Study)

TypeinterventionalSponsorMayo ClinicRan2016 to 2019Enrolled1,386ConditionsBreast CancerArmsWritten educational brochure, Promotora interaction
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karthik GhoshGeneral Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Sarah M JenkinsDivision of Clinical Trials and Biostatistics, Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jennifer L RidgewayRobert D. and Patricia E. Kern Center for Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
Jessica D AustinQuantitative Health Sciences, Mayo Clinic, Scottsdale, AZ, USA.
Bijan J BorahRobert D. and Patricia E. Kern Center for Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
Bhavika PatelDepartment of Radiology, Mayo Clinic, Phoenix, AZ, USA.
Deborah J RhodesDepartment of Internal Medicine, Yale University, New Haven, CT, USA.
Aaron D NormanDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street S.W., Biobusiness 5-81, Rochester, MN, 55905, USA.
Edna P RamosDepartment of Surgery, Mayo Clinic, Scottsdale, AZ, USA.
Matt JewettDepartment of Administration Mountain Park Health Center, Phoenix, AZ, USA.
Crystal R GonzalezDepartment of Integrated Nutrition Services and Collaborative Research, Mountain Park Health Center, Phoenix, AZ, USA.
Valentina HernandezDepartment of Integrated Nutrition Services and Collaborative Research, Mountain Park Health Center, Phoenix, AZ, USA.
Davinder SinghDepartment of Administration Mountain Park Health Center, Phoenix, AZ, USA.
Celine M VachonDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street S.W., Biobusiness 5-81, Rochester, MN, 55905, USA. vachon.celine@mayo.edu.
Vera J SumanDivision of Clinical Trials and Biostatistics, Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Behavioral and Psychological Impact of Returning Breast Density Results to LatinasR01MD009682 · NIMHD · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2016 to 2020
$2.6M
NCI NIH HHS P30 CA015083NIH HHS R01 MD09682NIMHD NIH HHS R01 MD009682
6 · The paper itself

Abstract

backgroundLaws mandating that women be informed of mammographic breast density (MBD) with their mammogram results may increase anxiety. We report on changes in self-reported levels of anxiety, worry about developing breast cancer (BC), as well as perceived risk of BC resulting from three MBD notification methods: usual care (mailed notification letter), enhanced care (usual care with MBD educational brochure), or interpersonal care (enhanced care with promotora education), among a Latina population.

methodsA randomized controlled clinical trial of three MBD notifications was performed among Latina women aged 40 to 74 years receiving screening mammography at a federally qualified health center (FQHC). Measures of anxiety, BC worry and perceived lifetime BC risk were assessed using a questionnaire. Anxiety was measured using the State-Trait Anxiety Inventory scale (STAI-S). The question: "How frequently do you worry about getting breast cancer someday" assessed BC worry. perceived lifetime risk of BC was rated between 0% (no chance) to 100% (definitely will get). Additional surveys were completed at two weeks to six months (T1) and one year (T2) after the intervention.

results1332 Latina women were randomized between October 2016 and October 2019. At T0, 51.8% had moderate or severe anxiety. BC worry was reported to be sometimes/ often/ almost all the time among 41.3% of participants. 25.4% reported a perceived lifetime risk of developing BC of > 10%, compared with 6.6% with Gail model estimated lifetime risk score of > 10%. There was no significant difference in the proportion of patients who maintained low or had decrease in their levels of anxiety, BC worry or perceived risk from T0 to either T1 or T2 surveys between intervention groups.

conclusionThis Latina cohort had high levels of anxiety and BC worry which persisted regardless of intervention received. Future work is needed to improve our understanding of factors that could lower anxiety and BC worry and improve BC risk perception in this population. CLINICAL

trial registrationClinicalTrials.gov, NCT02910986. Registered on 22/09/2016.

Indexed as

AnxietyBreast DensityBreast NeoplasmsHispanic or LatinoMammographyAdultAgedEarly Detection of CancerFemaleHumansMiddle AgedSurveys and QuestionnairesAnxietyBreast cancer worryBreast density notificationLatinasPerceived risk

Identifiers

PMID40452038
PMCPMC12128533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.