Evidence map›Paper›PMID 40452022›Full record

ArticleBMC molecular and cell biology2025

TRAIL (DR5) receptor and the modulation of TRAIL pathway in PLWHIV: key mechanisms in the progression of HIV disease.

Sarah Ratkovich-Gonzalez, Mariana Del Rocio Ruiz-Briseño, Judith Carolina De Arcos-Jiménez, Monserrat Alvarez-Zavala, Jaime Federico Andrade-Villanueva, Pedro Martínez-Ayala, Vida V Ruíz-Herrera, Luz Alicia Gonzalez-Hernandez, Karina Sánchez-Reyes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC molecular and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah Ratkovich-GonzalezMonterrey Institute of Technology and Higher Education, School of Medicine and Health Sciences, Avenida General Ramón Corona 2514 Nuevo México, Zapopan, Jalisco, 45138, Mexico.
Mariana Del Rocio Ruiz-BriseñoDepartment of Health-Disease as an Individual and Collective Process, CUTLAJO, University of Guadalajara, Carretera Tlajomulco, Santa Fé Km. 3.5 No.595, Lomas de Tejeda, Tlajomulco de Zúñiga, Jalisco, C. P. 45641, Mexico.
Judith Carolina De Arcos-JiménezDepartment of Health-Disease as an Individual and Collective Process, CUTLAJO, University of Guadalajara, Carretera Tlajomulco, Santa Fé Km. 3.5 No.595, Lomas de Tejeda, Tlajomulco de Zúñiga, Jalisco, C. P. 45641, Mexico.
Monserrat Alvarez-ZavalaHIV and Immunodeficiencies Research Institute (InIVIH), Department of Medical Clinics, CUCS, University of Guadalajara, Hospital 278, Guadalajara, Jalisco, CP 44280, Mexico.
Jaime Federico Andrade-VillanuevaHIV and Immunodeficiencies Research Institute (InIVIH), Department of Medical Clinics, CUCS, University of Guadalajara, Hospital 278, Guadalajara, Jalisco, CP 44280, Mexico.
Pedro Martínez-AyalaHIV Unit Department, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", Hospital 278, Guadalajara, Jalisco, CP 44280, Mexico.
Vida V Ruíz-HerreraHIV Unit Department, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", Hospital 278, Guadalajara, Jalisco, CP 44280, Mexico.
Luz Alicia Gonzalez-HernandezHIV and Immunodeficiencies Research Institute (InIVIH), Department of Medical Clinics, CUCS, University of Guadalajara, Hospital 278, Guadalajara, Jalisco, CP 44280, Mexico. luceroga08@gmail.com.
Karina Sánchez-ReyesHIV and Immunodeficiencies Research Institute (InIVIH), Department of Medical Clinics, CUCS, University of Guadalajara, Hospital 278, Guadalajara, Jalisco, CP 44280, Mexico. karina_reyesqfb@hotmail.com.

Funding

PRODEP NPTC 238710; 511-6/17-8091
6 · The paper itself

Abstract

backgroundHIV infection is mainly described by depletion of CD4

resultsExpression of TRAIL receptor DR5 in CD3

conclusionsIn PLWHIV before ART, the activation and regulation of TRAIL pathway shows to be an important regulator in cell depletion. The expression of TRAIL DR5 significantly increased in CD3

Indexed as

HIV InfectionsReceptors, TNF-Related Apoptosis-Inducing LigandTNF-Related Apoptosis-Inducing LigandAdultApoptosisBiomarkersCD4-Positive T-LymphocytesDisease ProgressionFemaleHumansMaleMiddle AgedMonocytesReceptors, CCR5Receptors, CXCR4Signal TransductionBiomarkersCCR5 protein, humanReceptors, CCR5Receptors, CXCR4Receptors, TNF-Related Apoptosis-Inducing LigandTNF-Related Apoptosis-Inducing LigandTNFSF10 protein, humanApoptosisCo-receptorsDR5FasFasLHIVIL-18InflammationTRAIL

Identifiers

PMID40452022
PMCPMC12128504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.