Evidence map›Paper›PMID 40451992›Full record

Observational studyCJEM2026

The increased mortality of older patients with moderate traumatic brain injury.

Chartelin Jean Isaac, Axel Benhamed, Valérie Boucher, Samuel Lauzon, Pierre-Gilles Blanchard, Christian Malo, Francis Bernard, Jean-Marc Chauny, Mélanie Bérubé, Eric Mercier and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in CJEM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chartelin Jean IsaacAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Axel BenhamedAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Valérie BoucherAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Samuel LauzonAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Pierre-Gilles BlanchardAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Christian MaloAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Francis BernardCentre Hospitalier de Sacré-Cœur, Montréal, QC, Canada.
Jean-Marc ChaunyCentre Hospitalier de Sacré-Cœur, Montréal, QC, Canada.
Mélanie BérubéAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Eric MercierAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Amaury GossiomeAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada.
Myreille D'AstousFaculté de Médecine, Université Laval, Québec, QC, Canada.
Marcel ÉmondAxe santé des populations et pratiques optimales en santé, CHU de Québec-Université Laval Research Center, Québec, QC, Canada. marcel.emond@fmed.ulaval.ca.ORCID 0000-0001-7158-8110

Funding

Fonds de Recherche du Québec - Santé 33239
6 · The paper itself

Abstract

purposeHigher mortality has been reported in older patients with moderate traumatic brain Injuries (TBI) compared to younger patients. To identify the risk factors associated with in-hospital mortality, complications and extended length of stay in moderate TBI patients.

methods

designa multicentre observational cohort study using the Quebec Trauma Registry. POPULATION: Hospitalized patients aged ≥ 16 with a moderate TBI (a head injury with an Abbreviated Injury Scale (AIS) ≥ 3, and a GCS score of 9-12). OUTCOMES: In-hospital mortality, complications and prolonged length of stay. ANALYSES: Multivariable logistic regression.

resultsWe included 1005 patients, 38.1% of whom were aged ≥ 65. The in-hospital mortality rate was 20.1%. Male sex (OR = 1.6 [95% CI:1.02-2.6], age (≥ 85 years old VS < 65 years) (OR = 18.7 [95% CI: 9.2-38.1]), ≥ 2 comorbidities (OR = 2.3 [95% CI: 1.3-4.0]), Injury Severity Score (OR = 1.04 [95% CI: 1.01-1.1]), presence of intraparenchymal hematoma (OR = 3.5 [95% CI: 2.2-5.5]) or other CT scan findings (cerebral edema, pneumocephalus, subpial hemorrhage, and pituitary injury) (OR = 1.9 [95% CI: 1.2-3.1]) were associated with increased odds of mortality. Male sex (OR = 1.8 [95% CI: 1.2-2.6]), age (65-74: OR = 1.7 [95% CI: 1.1-2.8] & 75-84: OR = 1.6 [95% CI: 1.03-2.6]), ≥ 2 comorbidities (OR = 2.9 [95% CI: 1.8-4.7]), thoraco-abdominal concomitant injury (OR = 2.0 [95% CI: 1.01-3.8]), and subarachnoid hemorrhage (OR = 7.6 [95% CI:1.5-38.5]) were associated with increased odds of complications. The number of comorbidities (≥ 2 OR = 1.7 [95% CI: 1.1-2.7]), spine injury (OR = 2.4 [95% CI: 1.4-4.1]), and delirium (OR = 3.1 [95% CI:1.8-5.2]) were associated with an increased odd of extended length of stay.

conclusionsThis study identified risk factors of in-hospital mortality, complications and extended length of stay, most of which are quickly available in the Emergency Department (ED). These factors could help clinicians identify moderate TBI patients at high risk of in-hospital mortality and guide shared decision-making regarding goals of care.

Indexed as

Brain Injuries, TraumaticRegistriesAbbreviated Injury ScaleAdultAgedAged, 80 and overAge FactorsFemaleGlasgow Coma ScaleHospital MortalityHumansInjury Severity ScoreLength of StayMaleMiddle AgedQuebecMortalityOlder patientsTraumatic brain injury

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.