Evidence map›Paper›PMID 40451974›Full record

ArticleBiomechanics and modeling in mechanobiology2025

A reduced 3D-0D fluid-structure interaction model of the aortic valve that includes leaflet curvature.

Ivan Fumagalli, Luca Dede', Alfio Quarteroni

Abstract read
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations.International journal for numerical methods in biomedical engineering · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ivan FumagalliMOX, Dipartimento di Matematica, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, Italy. ivan.fumagalli@polimi.it.
Luca Dede'MOX, Dipartimento di Matematica, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, Italy.
Alfio QuarteroniMOX, Dipartimento di Matematica, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, Italy.

Funding

HORIZON EUROPE European Research Council 101172493
6 · The paper itself

Abstract

We introduce an innovative lumped-parameter model of the aortic valve, designed to efficiently simulate the impact of valve dynamics on blood flow. Our reduced model includes the elastic effects associated with the leaflets' curvature and the stress exchanged with the blood flow. The introduction of a lumped-parameter model based on momentum balance entails an easier calibration of the model parameters: Phenomenological-based models, on the other hand, typically have numerous parameters. This model is coupled to 3D Navier-Stokes equations describing the blood flow, where the moving valve leaflets are immersed in the fluid domain by a resistive method. A stabilized finite element method with a BDF time scheme is adopted for the discretization of the coupled problem, and the computational results show the suitability of the system in representing the leaflet motion, the blood flow in the ascending aorta, and the pressure jump across the leaflets. Both physiological and stenotic configurations are investigated, and we analyze the effects of different treatments for the leaflet velocity on the blood flow.

Indexed as

Aortic ValveModels, CardiovascularAortaBiomechanical PhenomenaBlood Flow VelocityComputer SimulationFinite Element AnalysisHemodynamicsHumansHydrodynamicsStress, MechanicalAortic valve stenosisCardiac valve dynamicsComputational fluid dynamicsLumped-parameter modelReduced fluid–structure interactionResistive immersed implicit surface

Identifiers

PMID40451974
PMCPMC12245969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.