Evidence map›Paper›PMID 40451921›Full record

ArticleScientific reports2025

Deep learning driven interpretable and informed decision making model for brain tumour prediction using explainable AI.

Khan Muhammad Adnan, Taher M Ghazal, Muhammad Saleem, Muhammad Sajid Farooq, Chan Yeob Yeun, Munir Ahmad, Sang-Woong Lee

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khan Muhammad AdnanPattern Recognition and Machine Learning Lab, Faculty of Artificial Intelligence and Software, Gachon University, Seongnam-si, 13557, Republic of Korea.
Taher M GhazalDepartment of Networks and Cybersecurity, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, 19111, Jordan.
Muhammad SaleemChitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, 140401, India.
Muhammad Sajid FarooqDepartment of Cyber Security, NASTP Institute of Information Technology, Lahore, 58810, Pakistan.
Chan Yeob YeunCenter for Secure Cyber-Physical Systems (C2PS), Computer Science Department, Khalifa University, Abu Dhabi, United Arab Emirates. chan.yeun@ku.ac.ae.
Munir AhmadUniversity College, Korea University, Seoul, 02841, Republic of Korea.
Sang-Woong LeePattern Recognition and Machine Learning Lab, Faculty of Artificial Intelligence and Software, Gachon University, Seongnam-si, 13557, Republic of Korea. slee@gachon.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain Tumours are highly complex, particularly when it comes to their initial and accurate diagnosis, as this determines patient prognosis. Conventional methods rely on MRI and CT scans and employ generic machine learning techniques, which are heavily dependent on feature extraction and require human intervention. These methods may fail in complex cases and do not produce human-interpretable results, making it difficult for clinicians to trust the model's predictions. Such limitations prolong the diagnostic process and can negatively impact the quality of treatment. The advent of deep learning has made it a powerful tool for complex image analysis tasks, such as detecting brain Tumours, by learning advanced patterns from images. However, deep learning models are often considered "black box" systems, where the reasoning behind predictions remains unclear. To address this issue, the present study applies Explainable AI (XAI) alongside deep learning for accurate and interpretable brain Tumour prediction. XAI enhances model interpretability by identifying key features such as Tumour size, location, and texture, which are crucial for clinicians. This helps build their confidence in the model and enables them to make better-informed decisions. In this research, a deep learning model integrated with XAI is proposed to develop an interpretable framework for brain Tumour prediction. The model is trained on an extensive dataset comprising imaging and clinical data and demonstrates high AUC while leveraging XAI for model explainability and feature selection. The study findings indicate that this approach improves predictive performance, achieving an accuracy of 92.98% and a miss rate of 7.02%. Additionally, interpretability tools such as LIME and Grad-CAM provide clinicians with a clearer understanding of the decision-making process, supporting diagnosis and treatment. This model represents a significant advancement in brain Tumour prediction, with the potential to enhance patient outcomes and contribute to the field of neuro-oncology.

Indexed as

Brain NeoplasmsDecision MakingDeep LearningFemaleHumansMagnetic Resonance ImagingMalePrognosisTomography, X-Ray ComputedBrain tumourCT scansMRIXAI

Identifiers

PMID40451921
PMCPMC12127443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.