Evidence map›Paper›PMID 40451847›Full record

ArticleScientific reports2025

The presence of neutralizing antibodies against omicron subvariants among a vaccinated cohort at one year after the first dose of vaccination in Malaysia.

Eida Nurhadzira Muhammad, Zhuo Lin Chong, Mohd Amierul Fikri Mahmud, Filza Noor Asari, Rozainanee Mohd Zain, Masita Arip

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eida Nurhadzira MuhammadCenter for Communicable Disease Epidemiology Research, Institute for Public Health, National Institute of Health, Shah Alam, Selangor, Malaysia. enurhadzira@gmail.com.ORCID http://orcid.org/0000-0001-7061-4698
Zhuo Lin ChongCenter for Communicable Disease Epidemiology Research, Institute for Public Health, National Institute of Health, Shah Alam, Selangor, Malaysia.
Mohd Amierul Fikri MahmudCenter for Communicable Disease Epidemiology Research, Institute for Public Health, National Institute of Health, Shah Alam, Selangor, Malaysia.
Filza Noor AsariCenter for Communicable Disease Epidemiology Research, Institute for Public Health, National Institute of Health, Shah Alam, Selangor, Malaysia.
Rozainanee Mohd ZainInfectious Disease Research Centre, Institute for Medical Research, National Institute of Health, Shah Alam, Selangor, Malaysia.
Masita AripAllergy and Immunology Research Centre, Institute for Medical Research, National Institute of Health, Shah Alam, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assesses the neutralizing antibodies response to Omicron subvariants and examines factors associated with seropositivity in a vaccinated Malaysian cohort. It is a prospective cohort study, conducted between June 2021 and October 2022. Descriptive and binary logistic regression analyses were performed on 1,117 adults aged 18 and above. Among the subvariants, seropositivity rates were: BA.2 (81.9%), BA.1 (68.4%), and BA.4/5 (64.2%). Non-Malaysians had significantly higher odds of testing positive for BA.2 compared to Malaysians (OR: 8.009; 95% CI: 1.273-50.402). Recipients of AstraZeneca (OR: 3.955; 95% CI: 2.414-6.482) and CanSino (OR: 1.980; 95% CI: 1.047-3.743) vaccines had higher odds of BA.2 seropositivity compared to Pfizer recipients. For BA.4/5, individuals aged 60 and above had greater odds of seropositivity (OR: 1.751; 95% CI: 1.029-2.979) compared to those aged 18-39. Chinese ethnicity was associated with lower odds of seropositivity than Malay ethnicity across BA.1 (OR: 0.508; 95% CI: 0.350-0.736), BA.2 (OR: 0.570; 95% CI: 0.377-0.861), and BA.4/5 (OR: 0.671; 95% CI: 0.467-0.963). This study highlights that completing primary vaccination and booster doses remains critical to reducing severe COVID-19 outcomes, underscoring the need for ongoing surveillance and targeted strategies for vulnerable demographic and socio-environmental groups.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesSARS-CoV-2AdolescentAdultAgedFemaleHumansMalaysiaMaleMiddle AgedProspective StudiesVaccinationYoung AdultAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesMalaysiaNeutralizing antibodiesOmicron BA.1, BA.2, and BA.4/5Omicron variantsVaccinated cohort

Identifiers

PMID40451847
PMCPMC12127458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.