Evidence map›Paper›PMID 40451639›Full record

ReviewBest practice & research. Clinical gastroenterology2025

Screening for and surveillance of premalignant conditions of the stomach.

Irina Luzko, Leticia Moreira, Jan Bornschein

Abstract readReview
In one paragraph

Review in Best practice & research. Clinical gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Irina LuzkoDepartment of Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), CIBEREHD, Spain; Facultat de Medicina, Universitat de Barcelona, Barcelona, 08036, Spain.
Leticia MoreiraDepartment of Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), CIBEREHD, Spain; Facultat de Medicina, Universitat de Barcelona, Barcelona, 08036, Spain.
Jan BornscheinMedical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK; Translational Gastroenterology and Liver Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK. Electronic address: jan.bornschein@rdm.ox.ac.uk.

Funding

Medical Research Council MR/W029960/1
6 · The paper itself

Abstract

Strategies for population-based screening are thus far only implemented in high incidence countries such as South Korea or Japan with data showing a positive impact on gastric cancer mortality. Screening in most Western countries is deemed not cost-effective as these are mainly classified as low or intermediate risk regions. This is in part due to high costs for endoscopy as the diagnostic gold-standard. Blood testing for serum pepsinogens is implemented as a pre-screening tool in some Asian countries but can better highlight mucosal atrophy than the cancer itself. Endoscopic surveillance of patients with advanced preneoplastic conditions allows detection of early neoplastic lesions that can be treated endoscopically, resulting in better outcome, and is hence now also recommended by several European countries. However, there is no uniform approach, so screening and surveillance strategies need to take regional characteristics into account including gastric cancer incidence and cost for endoscopy among others.

Indexed as

Early Detection of CancerMass ScreeningPrecancerous ConditionsStomach NeoplasmsCost-Benefit AnalysisGastroscopyHumansIncidencePepsinogen APepsinogensPopulation SurveillanceRisk FactorsPepsinogen APepsinogensEarly diagnosisGastric cancerScreeningSurveillance

Identifiers

PMID40451639
PMCPMC7618190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.