ArticleEuropean journal of haematology2025
Efficacy and Safety of Bendamustine-Rituximab for Nodular Lymphocyte Predominant Hodgkin Lymphoma.
Article in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Efficacy and Safety of Bendamustine-Rituximab for Nodular Lymphocyte Predominant Hodgkin Lymphoma.European journal of haematology · 2025Article
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Authors and funding
7 authors.
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Abstract
introductionBendamustine-rituximab (BR) has demonstrated efficacy and tolerability in the treatment of various indolent B-cell lymphomas, but there is limited data regarding its outcomes in nodular lymphocyte predominant B-cell (Hodgkin) lymphoma (NLPBL).
methodsThis retrospective, population-based study included consecutive patients ≥ 18 years old who received BR for NLPBL in Alberta, Canada.
resultsThe study population comprised 23 patients with a median age of 39 years (range 18-74) who received BR for treatment-naive (n = 17) or relapsed/refractory (n = 6) NLPBL. Advanced stage disease was present in 18 (78%), splenic involvement in 9 (39%), and bone marrow involvement in 8 (35%) patients. The response rate to BR was 100%, with a complete response in 78% and a partial response in 22%. After a median follow-up of 4.3 years (range 0.8-9.0), the 4-year progression-free survival and overall survival rates were 83% (95% CI: 55%-94%) and 87% (95% CI: 58%-97%) for all patients and 84% (95% CI: 50%-96%) and 91% (95% CI: 51%-99%) for recipients of first-line BR, respectively. The safety profile was in keeping with the known toxicities of BR, with the most common adverse events consisting of neutropenia, rash, and infusion reactions.
conclusionThese findings suggest that BR is a promising treatment option for NLPBL, with a favorable efficacy and safety profile.
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