Evidence map›Paper›PMID 40451618›Full record

ArticleAsian spine journal2025

Associations between preoperative opioids, posthospitalization discharge disposition, and long-term opioid prescribing after spine surgery: a population-based cohort study.

Savannah Rose Whitfield, Andrew Charles Hanson, Erica Bellamkonda, Maria Mendoza De La Garza, Xander Schmidt, William Michael Hooten, Nafisseh Sirjani Warner

Abstract read
In one paragraph

Article in Asian spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Savannah Rose WhitfieldDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Andrew Charles HansonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Erica BellamkondaDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Maria Mendoza De La GarzaDivision of Community Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Xander SchmidtDepartment of Internal Medicine, Oregon Health and Science University, Portland, OR, USA.
William Michael HootenDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Nafisseh Sirjani WarnerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Prescription opioids, cognitive decline, and Alzheimer's disease in older adultsK23AG070113 · NIA · MAYO CLINIC ROCHESTER · PI WARNER, NAFISSEH S · 2021 to 2025
$818k
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437k
NIA NIH HHS K23 AG070113NIA NIH HHS K23AG070113NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

STUDY

designA retrospective cohort study. PURPOSE: To evaluate the association between preoperative opioid use and discharge disposition following major spine surgery and between discharge disposition and opioid availability through 1 year postoperatively. OVERVIEW OF LITERATURE: Preoperative opioid use is prevalent in spine surgery and is associated with larger postoperative opioid consumption, longer hospitalizations, increased healthcare expenses, and greater risk of surgical revision. However, whether preoperative opioid use is associated with discharge disposition following major spine surgery, which may serve as an indicator of postoperative functional recovery, remains unclear.

methodsThis retrospective population-based cohort study incorporated comprehensive prescription opioid information for 2223 adults (age ≥18 years) undergoing spine surgery in Olmsted County, Minnesota, between January 1, 2005, and December 31, 2016. Multivariable models were employed to assess the relationships among preoperative opioid exposures, postoperative opioid exposures, and discharge disposition (home, inpatient rehabilitation facility [IRF], and skilled nursing facility [SNF]).

resultsA total of 2,223 adults were included with the following preoperative opioid availability: none (778 [35.0%]), short term (1,118 [50.3%]), episodic (227 [10.2%]), and long term (100 [4.5%]). Discharge dispositions were home (1,984 [89.2%]), IRF (94 [4.2%]), and SNF (145 [6.5%]). Compared with patients with no preoperative opioid availability, those with short-term or episodic opioid availability are less likely to be discharged to an IRF (odds ratio [OR], 0.56; 95% confidence interval [CI], 0.36-0.87; p=0.010). Patients with long-term opioid availability had significantly increased odds of SNF discharge (OR, 2.93; 95% CI, 1.39-6.17; p=0.005). At 1-year follow-up, patients discharged to IRF had an increased likelihood of long-term postoperative opioid availability compared with those discharged home (OR, 12.49; 95% CI, 4.84-32.24; p<0.001).

conclusionsPreoperative opioid prescribing was associated with post-hospitalization discharge disposition, which in turn was associated with opioid prescribing patterns 1 year postoperatively. Assessing opioid prescribing trends preoperatively may guide discussions regarding anticipated discharge disposition following spine surgery.

Indexed as

Opioid: Postoperative periodPatient dischargeSpineSurgery

Identifiers

PMID40451618
PMCPMC12400098

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