ArticleThe Journal of pediatrics2025
Prenatal Adversity and Neonatal White Matter Microstructure Independently Relate to Language Outcomes at Age 2 Years.
Article in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Adverse Childhood Experiences in the First 1000 Days of Life and Dental Caries Experience From Age 31 to 61 Months.Journal of public health dentistry · 2025Article
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14 authors.
Funding
Abstract
objectiveTo examine the mediating and moderating associations between prenatal exposure to adversity and neonatal white matter (WM) development on language outcomes at age 2 years. STUDY
designThis longitudinal study includes 160 infants (gestational ages 41 - 39 weeks, n = 83; 38 - 37 weeks, n = 62; 36 - 34 weeks, n = 15) with neonatal diffusion MRI and language assessments at age 2 years using the Bayley Scales of Infant and Toddler Development-III. Prenatal social disadvantage (PSD) and maternal psychosocial stress were assessed throughout the prenatal period. Multivariable and stepwise linear regression, mediation, and moderation analyses were used to investigate associations between prenatal adversities and neonatal WM on language outcomes. Maternal cognition and stimulation provided in the home were included as covariates.
resultsPSD and maternal psychosocial stress were associated with poorer language outcomes (P < .001). When PSD and maternal Psychosocial Stress were modeled simultaneously, only PSD was associated with language outcomes (P < .001). Independent of PSD (P < .001), lower neonatal fractional anisotropy (FA) in the corpus callosum (CC) was associated with poorer language outcomes (P = .02). CC FA did not mediate the association between PSD and language outcomes (indirect effect 95% CIs: -0.96 - 0.15), and there was no interaction between PSD and CC FA on language outcomes (P > .05).
conclusionsPSD and neonatal CC FA were independently related to language outcomes, with no significant mediating or moderating pathways at this stage of development. These findings suggest the need for investigation of prenatal provision of poverty-reducing services and maternal psychosocial intervention services to promote offspring WM and language development.
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