ArticleMolecular and cellular neurosciences2025
Peroxisome, neuropeptide, and inflammation signaling pathways uniquely impacted by opioid exposure in the hypothalamus of males and females.
Article in Molecular and cellular neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Metabolite profiling of the effect of prenatal stimuli across postnatal treatments in the liver.Molecular and cellular endocrinology · 2026Article
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Abstract
Synaptic plasticity is a recognized neuroadaptation of the brain in response to environmental cues. In addition, differences between females and males in neuronal plasticity in response to opioids have been reported. However, the response to opioids in the hypothalamus, a structure that encompasses sexually dimorphic nuclei, is partially characterized. Furthering the characterization of the sex-dependent dysregulation of gene networks, the hypothalamus transcriptome was profiled in female and male pigs that were exposed to morphine relative to controls. Among the 923 genes that were differentially expressed (FDR-adjusted p-value <0.05) across treatments and sexes, 179 genes were identified between saline and morphine-treated females, and 129 genes were identified between saline-treated females and males. The under-expression of genes in the morphine-exposed relative to the saline groups in both sexes characterized the enrichment of the peroxisome pathway and neuropeptide signaling process whereas the opposite pattern characterized the enrichment of the glutamatergic synapse pathway in females. The neuropeptide pathway included differentially expressed neuropeptide and corresponding receptor genes, including Npy and its family receptors, Penk, Pomc, and Tac1, and the peroxisome pathway included Mvk and Dao and the Hmgc family of genes. The effect of morphine treatment in males was detected in the enrichment of the interleukin-17 and T cell receptor signaling pathways. These results offer further evidence that chronic morphine exposure evokes distinct molecular mechanism disruption in females and males, highlighting the need for sex-dependent molecular target therapies.
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