Evidence map›Paper›PMID 40451261›Full record

ArticleBMJ health & care informatics2025

GenECG: a synthetic image-based ECG dataset to augment artificial intelligence-enhanced algorithm development.

Neil Bodagh, Kyaw Soe Tun, Adam Barton, Malihe Javidi, Darwon Rashid, Rachel Burns, Irum Kotadia, Magda Klis, Ali Gharaviri, Vinush Vigneswaran and 4 more

Abstract read
In one paragraph

Article in BMJ health & care informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Neil BodaghSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK neil.bodagh@kcl.ac.uk.ORCID http://orcid.org/0000-0001-5475-5298
Kyaw Soe TunGuy's and St Thomas' NHS Foundation Trust, London, UK.
Adam BartonNeurolabs, Edinburgh, UK.
Malihe JavidiCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Darwon RashidCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Rachel BurnsCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Irum KotadiaSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Magda KlisSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Ali GharaviriCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Vinush VigneswaranCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Steven NiedererSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Mark O'NeillSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Miguel O Bernabeu *Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Steven E Williams *School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectivesAn image-based ECG dataset incorporating visual imperfections common to paper-based ECGs, which are typically scanned or photographed into electronic health records, could facilitate clinically useful artificial intelligence (AI)-ECG algorithm development. This study aimed to create a high-fidelity, synthetic image-based ECG dataset.

methodsECG images were recreated from the PTB-XL database, a signal-based dataset and image manipulation techniques were applied to mimic imperfections associated with ECGs in real-world settings. Clinical Turing tests were conducted to evaluate the fidelity of the synthetic images, and the performance of current AI-ECG algorithms was assessed using synthetic images containing visual imperfections.

resultsGenECG, an image-based dataset containing 21 799 ECGs with visual imperfections encountered in routine clinical care paired with imperfection-free images, was created. Turing tests confirmed the realism of the images: expert observer accuracy of discrimination between real-world and synthetic ECGs fell from 63.9% (95% CI 58.0% to 69.8%) to 53.3% (95% CI 48.6% to 58.1%) over three rounds of testing, indicating that observers could not distinguish between synthetic and real ECGs. The performance of pre-existing algorithms on synthetic (area under the curve (AUC) 0.592, 95% CI 0.421 to 0.763) and real-world (AUC 0.647, 95% CI 0.520 to 0.774) ECG images containing imperfections was limited. Algorithm fine-tuning with GenECG data improved real-world ECG classification accuracy (AUC 0.821, 95% CI 0.730 to 0.913) demonstrating its potential to augment image-based algorithm development. DISCUSSION/

conclusionGenECG is the first synthetic image-based ECG dataset to pass a clinical Turing test. The dataset will enable image-based AI-ECG algorithm development, ensuring utility in low resource areas, prehospital settings and hospital environments where signal data are unavailable.

Indexed as

AlgorithmsArtificial IntelligenceElectrocardiographyDatabases, FactualElectronic Health RecordsHumansArtificial intelligenceData Science

Identifiers

PMID40451261
PMCPMC12142132

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.