Evidence map›Paper›PMID 40451247›Full record

ArticleHLA2025

Asymptomatic SARS-CoV-2 Infection: Association Involving the HLA-B*15 Allele Group in Brazilian Individuals.

Christiane Maria Ayo, Henrique Magalhães, Marcos Paulo Miola, Cinara Cássia Brandão, Maurício Lacerda Nogueira, Cássia Fernanda Estofolete, Victor Hugo de Souza, Jeane Eliete Laguila Visentainer, Luiz Carlos de Mattos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HLA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christiane Maria AyoDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Imunogenética, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.ORCID 0000-0003-3983-0119
Henrique MagalhãesDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Imunogenética, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Marcos Paulo MiolaDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Imunogenética, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Cinara Cássia BrandãoDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Imunogenética, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.ORCID 0000-0002-4836-3113
Maurício Lacerda NogueiraDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Pesquisa Em Virologia, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Cássia Fernanda EstofoleteDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Pesquisa Em Virologia, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Victor Hugo de SouzaDepartamento de Ciências Básicas da Saúde, Laboratório de Imunogenética, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil.
Jeane Eliete Laguila VisentainerDepartamento de Ciências Básicas da Saúde, Laboratório de Imunogenética, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil.ORCID 0000-0002-5815-7903
Luiz Carlos de MattosDepartamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Imunogenética, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 20/04836-0Fundação de Amparo à Pesquisa do Estado de São Paulo 20/06471-9
6 · The paper itself

Abstract

The aim of this study was to investigate the influence of HLA-A, -B and -C polymorphisms on the clinical course of SARS-CoV-2 infection and on the progression of COVID-19 in a population from southeastern Brazil. This study included 478 unvaccinated individuals. Of these, 369 were hospitalised with critical/severe (n = 309) or moderate/mild (n = 60) symptoms, and 109 were asymptomatic. The control group consisted of 150 volunteer bone marrow donors, recruited in the pre-pandemic period. The HLA-B*15 allele group (adjusted p value < 0.001) was associated with a protective factor against symptomatic infection. Investigating the effects of the distribution of HLA alleles on susceptibility and resistance to SARS-CoV-2 may provide a better understanding of the clinical course of infection in different geographical regions.

Indexed as

COVID-19HLA-B15 AntigenSARS-CoV-2AdultAgedAllelesAsymptomatic InfectionsBrazilFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, GeneticHLA-B15 AntigenasymptomaticCOVID‐19HLA Class ISARS‐CoV‐2

Identifiers

PMID40451247
PMCPMC12127060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.