Evidence map›Paper›PMID 40451130›Full record

ArticleThe journal of physiological sciences : JPS2025

Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1.

Masao Kakoki, John R Hagaman, Masahiko Terajima, Masako Nagasawa, Katsumi Uoshima, Mitsuo Yamauchi, Oliver Smithies, Kenji Kansaku

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masao KakokiDepartment of Physiology, Dokkyo Medical University, 880 Kitakobayashi, Shimotsuga district, Mibu, Tochigi 321-0293, Japan. Electronic address: m-kakoki@dokkyomed.ac.jp.
John R HagamanDepartment of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Masahiko TerajimaDepartment of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
Masako NagasawaDivision of Bioprosthodontics, Faculty of Dentistry & Graduate School of Medical and Dental sciences, Niigata University, Niigata 951-8514, Japan.
Katsumi UoshimaDivision of Bioprosthodontics, Faculty of Dentistry & Graduate School of Medical and Dental sciences, Niigata University, Niigata 951-8514, Japan.
Mitsuo YamauchiDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Oliver SmithiesDepartment of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kenji KansakuDepartment of Physiology, Dokkyo Medical University, 880 Kitakobayashi, Shimotsuga district, Mibu, Tochigi 321-0293, Japan.

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
Collagen Glycosylation, Maturation and MineralizationR21AR060978 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAMAUCHI, MITSUO · 2012 to 2013
$352k
NHLBI NIH HHS R01 HL049277NIAMS NIH HHS R21 AR060978NIDDK NIH HHS P30 DK034987
6 · The paper itself

Abstract

In humans, loss-of-function mutations in multiple component genes of transforming growth factor (TGF)-β signaling have been demonstrated to cause proximal aortic aneurysms. However, association of human variants in the prototype ligand TGFB1 with thoracic aortic aneurysms have not been reported to date. To delineate the consequences of genetically altered Tgfb1 expression on aortic phenotype in mammals, we studied aortic phenotype in mice with loss-of-functions or gain-of-function mutations in Tgfb1 (Tgfb1

Indexed as

Aortic AneurysmAortic Aneurysm, ThoracicTransforming Growth Factor beta1AnimalsAortaCollagenElastinMaleMiceMice, Inbred C57BLMutationCollagenElastinTgfb1 protein, mouseTransforming Growth Factor beta13’ untranslated regionExtracellular matrixGene titration

Identifiers

PMID40451130
PMCPMC12162004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.