Evidence map›Paper›PMID 40450915›Full record

ArticleHearing research2025

Prevention and treatment of noise-induced hearing loss and cochlear synapse degeneration by potassium channel blockers in vivo.

Hong-Bo Zhao, Li-Man Liu, Xiaoling Lu, Auraemil T Quinonez, Rafael A Roberts, Tian-Ying Zhai, Chun Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hong-Bo ZhaoDepartment of Surgery - Otolaryngology, Yale University Medical School, 310 Cedar Street, New Haven, CT, USA, 06510; Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, USA, 40536. Electronic address: hong-bo.zhao@yale.edu.
Li-Man LiuDepartment of Surgery - Otolaryngology, Yale University Medical School, 310 Cedar Street, New Haven, CT, USA, 06510; Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, USA, 40536.
Xiaoling LuDepartment of Surgery - Otolaryngology, Yale University Medical School, 310 Cedar Street, New Haven, CT, USA, 06510.
Auraemil T QuinonezDepartment of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, USA, 40536.
Rafael A RobertsDepartment of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, USA, 40536.
Tian-Ying ZhaiDepartment of Surgery - Otolaryngology, Yale University Medical School, 310 Cedar Street, New Haven, CT, USA, 06510.
Chun LiangDepartment of Surgery - Otolaryngology, Yale University Medical School, 310 Cedar Street, New Haven, CT, USA, 06510.

Funding

The effect of noise induced hearing loss on Alzheimer's disease development and progressionRF1AG082216 · NIA · YALE UNIVERSITY · PI ZHAO, HONG-BO · 2023 to 2023
$2.4M
ATP-purinergic mechanisms underlying noise-induced cochlear synaptopathy and hearing lossR01DC017025 · NIDCD · YALE UNIVERSITY · PI ZHAO, HONG-BO · 2018 to 2022
$1.9M
NIA NIH HHS RF1 AG082216NIDCD NIH HHS R01 DC017025
6 · The paper itself

Abstract

Noise can induce hearing loss. In particular, noise can induce cochlear synapse degeneration leading to hidden hearing loss, which is the most common type of hearing disorders in the clinic. Currently, there is no pharmacological treatment, especially no post-exposure (i.e., therapeutic) treatment available in the clinic. Here, we report that systemic administration of K

Indexed as

CochleaHearingHearing Loss, Noise-InducedPotassium Channel BlockersSynapsesTetraethylammoniumAcoustic StimulationAnimalsAuditory ThresholdDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHair Cells, Auditory, InnerLarge-Conductance Calcium-Activated Potassium ChannelsMaleOtoacoustic Emissions, SpontaneousLarge-Conductance Calcium-Activated Potassium ChannelsPotassium Channel BlockersTetraethylammoniumAcoustic startle responseBK channelCochlear synaptopathyGAL-021Hidden hearing lossK channel blockerK(+)-excitotoxicityPost-noise exposure treatment

Identifiers

PMID40450915
PMCPMC12318480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.