Trial reportJournal of geriatric oncology2025
Fatigue, physical function, and the context of social vulnerability for older adults with cancer.
Trial report in Journal of geriatric oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02054741 (A Geriatric Assessment Intervention for Patients Aged 70 and Over Receiving Chemotherapy or Similar Agents for Advanced Cancer), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Geriatric Assessment Intervention for Patients Aged 70 and Over Receiving Chemotherapy or Similar Agents for Advanced Cancer: Reducing Toxicity in Older Adults
Who cites it
2 citing papers in PubMed.
- The association between radiographic osteosarcopenia and overall mortality among older patients undergoing colorectal cancer resection.Aging clinical and experimental research · 2026Article
- The Impact of Social Vulnerability on Exercise Outcomes: A Longitudinal Study of Physical Function in Older People With HIV.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionOlder adults with cancer-related fatigue often experience impairments in their physical function. Social determinants of health (SDOH) at the individual and community level may mean some patients have fewer resources to deal with fatigue and are at greater risk for decline in physical function. MATERIALS AND
methodsWe analyzed patients age ≥ 70 with advanced cancer and ≥ 1 aging-related impairment who were starting new treatment regimens with a high risk of toxicity in a nationwide cluster-randomized clinical trial (NCT02054741, UG1CA189961). Patient-Reported Outcome Common Terminology Criteria for Adverse Events (PROC-CTCAE) fatigue severity (0-4 points) was collected at baseline, Short Physical Performance Battery (SPPB, a measure of physical function, 0-12 points) at baseline, 4-6 weeks, 3 months, and 6 months. SDOH in the county where patients lived were measured by the Social Vulnerability Index (SVI, a measure reflecting community vulnerability, 0 to 1, higher = worse). We estimated adjusted relative risk (RR) of ≥1 point SPPB decline at 4-6 weeks associated with baseline fatigue. In exploratory analyses we estimated: (1) this association at 3 and 6 months, (2) moderation of this association by SVI.
resultsOut of 718 patients, we analyzed 600 with SPPB assessed at ≥1 follow up timepoint. Half reported fatigue that was moderate or greater, and 38.8 % declined in SPPB by 4-6 weeks. Mean SVI was 0.42 (SD 0.23). Greater fatigue was associated with increased risk of SPPB decline at 4-6 weeks (RR 1.21; 95 % CI 1.09, 1.34, p < 0.001), but not 3 or 6 months. The association at 4-6 weeks was not significantly different for patients living in areas with the least vulnerable quartile of SVI (RR 1.27, 95 % CI 1.05, 1.53) vs. the most vulnerable (RR 1.22, 95 % CI 0.91, 1.65; p = 0.85). DISCUSSION: Fatigue is associated with decline in physical function among older adults with advanced cancer and does not vary by social vulnerability. These results emphasize the importance of assessing and managing fatigue in this population.
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