ArticleCell reports2025
Widespread impact of nucleosome remodelers on transcription at cis-regulatory elements.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions.Genetics · 2026Article
- Mechanisms of gene regulation by SRCAP and H2A.Z.Nature communications · 2026Article
- Article
- CFDP1 is required for histone variant H2A.Z deposition by the human SRCAP chromatin remodeling complex.bioRxiv : the preprint server for biology · 2025Article
- esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions.bioRxiv : the preprint server for biology · 2025Article
- A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes.Nucleic acids research · 2025Article
- Reciprocal Regulation Between the SCFbioRxiv : the preprint server for biology · 2025Article
- H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells.Epigenetics & chromatin · 2024Article
- Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex.Science (New York, N.Y.) · 2024Article
Corrections and comments
- Update of
Authors and funding
3 authors.
Funding
Abstract
Nucleosome remodelers and regulatory factors collaborate to establish chromatin environments that control gene expression through cis-regulatory elements (CREs) such as promoters and enhancers, which drive transcription of mRNAs and CRE-associated non-coding RNAs (ncRNAs). Two CRE-associated ncRNAs include upstream antisense RNAs (uaRNAs) and enhancer RNAs (eRNAs). The role of remodelers in regulating CRE activity remains incompletely understood. Here, we investigated how SNF2-family remodelers regulate mRNA, eRNA, and uaRNA transcription in murine embryonic stem cells. We identified thousands of misregulated transcripts upon remodeler depletion and defined contributions of understudied remodelers. We find that paired mRNAs and eRNAs are co-regulated, while mRNAs and uaRNAs sharing a promoter are independently regulated by remodelers. Mechanistic studies reveal that CHD8 and SRCAP modulate transcription through canonical transcription factor and histone variant mechanisms, while other remodelers, including SMARCAL1, impact transcription indirectly by maintaining genomic stability. Our findings define classes of SNF2 remodelers in regulating the CRE-associated transcriptome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.