Evidence map›Paper›PMID 40450686›Full record

ArticleCell reports2025

Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells.

Zixuan Peng, Vijayaraj Nagarajan, Reiko Horai, Yingyos Jittayasothorn, Mary J Mattapallil, Rachel R Caspi

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  7. Article
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  10. Memory CD4Frontiers in immunology · 2026
    Review
  11. Article
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  13. Article
  14. Article
  15. The role of inflammation in myopic retinopathy.Frontiers in ophthalmology · 2025
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Zixuan PengLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA; Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China.
Vijayaraj NagarajanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Reiko HoraiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Yingyos JittayasothornLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Mary J MattapallilLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: mattapallilm@nei.nih.gov.
Rachel R CaspiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: caspir@nei.nih.gov.

Funding

T-CELL LINES AND CLONES IN UVEITAZ01EY000184 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 1985 to 2008
$6.6M
Intramural NIH HHS Z01 EY000184Intramural NIH HHS Z99 EY999999
6 · The paper itself

Abstract

Despite ocular immune privilege, circulating retina-specific T cells can trigger autoimmune uveitis, yet intraocular bleeding-a relatively common event-rarely leads to disease. Using an in vivo immune privilege model, we previously reported that all naive retina-specific T cells entering the eye become primed in situ; about 30% become Foxp3

Indexed as

Clonal AnergyEyeImmune PrivilegeT-Lymphocytes, RegulatoryTranscriptomeAnimalsMiceMice, Inbred C57BLRetinaUveitisautoimmune uveitisCP: Immunologyimmune toleranceocular immune privilegesingle-cell transcriptomicsT cell anergyTregs

Identifiers

PMID40450686
PMCPMC12307573

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.